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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway

  • Authors:
    • Jing Chang
    • Xin Xue
    • Chunli Song
    • Bin Liu
    • Lihua Gao

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China, Department of Cardiovascular, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
  • Pages: 5627-5632
    |
    Published online on: August 16, 2017
       https://doi.org/10.3892/mmr.2017.7254
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Abstract

Ginkgolide B is one of the components extracted from Folium Ginkgo. It is a natural antagonist of platelet‑activating factor receptor and has multiple pharmacological applications. In the present study, the effect of ginkgolide B on the proliferation of endothelial progenitor cells (EPCs) was examined, as well as its potential underlying mechanism. EPCs were cultured in various concentrations of ginkgolide B (0, 1.25, 5, 20, 80 or 160 µg/ml) for 24 or 48 h and then numbers of viable cells, apoptosis rate and caspace‑3 activity were measured. The results demonstrated that ginkgolide B treatment effectively promoted EPC growth, and suppressed cell apoptosis and caspase‑3 activity compared with control cells. In addition, ginkgolide B treatment significantly induced the expression of miR‑126, vascular endothelial growth factor and endothelial nitric oxide synthase, while it increased phosphorylation of AKT serine/threonine kinase 1 (Akt) and of p38 mitogen‑activated protein kinase in EPCs. The present study therefore demonstrated that ginkgolide B promoted cell growth in EPCs through overexpression of miR‑126 and activation of the Akt signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Chang J, Xue X, Song C, Liu B and Gao L: Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway. Mol Med Rep 16: 5627-5632, 2017.
APA
Chang, J., Xue, X., Song, C., Liu, B., & Gao, L. (2017). Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway. Molecular Medicine Reports, 16, 5627-5632. https://doi.org/10.3892/mmr.2017.7254
MLA
Chang, J., Xue, X., Song, C., Liu, B., Gao, L."Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway". Molecular Medicine Reports 16.4 (2017): 5627-5632.
Chicago
Chang, J., Xue, X., Song, C., Liu, B., Gao, L."Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway". Molecular Medicine Reports 16, no. 4 (2017): 5627-5632. https://doi.org/10.3892/mmr.2017.7254
Copy and paste a formatted citation
x
Spandidos Publications style
Chang J, Xue X, Song C, Liu B and Gao L: Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway. Mol Med Rep 16: 5627-5632, 2017.
APA
Chang, J., Xue, X., Song, C., Liu, B., & Gao, L. (2017). Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway. Molecular Medicine Reports, 16, 5627-5632. https://doi.org/10.3892/mmr.2017.7254
MLA
Chang, J., Xue, X., Song, C., Liu, B., Gao, L."Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway". Molecular Medicine Reports 16.4 (2017): 5627-5632.
Chicago
Chang, J., Xue, X., Song, C., Liu, B., Gao, L."Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway". Molecular Medicine Reports 16, no. 4 (2017): 5627-5632. https://doi.org/10.3892/mmr.2017.7254
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