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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2017 Volume 16 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells

  • Authors:
    • Li Qian
    • Wenyan Chen
    • Shaoqing Wang
    • Yang Liu
    • Xiaoqin Jia
    • Yi Fu
    • Weijuan Gong
    • Fang Tian

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
  • Pages: 5693-5698
    |
    Published online on: August 17, 2017
       https://doi.org/10.3892/mmr.2017.7269
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Abstract

Toll‑like receptors (TLRs) serve a vital role in activating the innate immune system by sensing conserved microbial products. Fc γ receptor IIb (FcγRIIb), the inhibitory Fc receptor, exerts its immune regulatory functions by binding to the immunoglobulin G Fc domain. Although the individual roles of TLRs and FcγRIIb have been studied intensively, the cross‑talk between FcγRIIb and TLR4 on B cells remains unknown. The present study demonstrated that FcγRIIb ligation by the immune complex (IC) attenuated the TLR4‑triggered nuclear factor (NF)‑κΒ activation, and decreased the release of interleukin (IL)‑6 from B cells, via enhancing LYN proto‑oncogene (Lyn) phosphorylation. In addition, IC treatment protected mice from lethal endotoxic shock. Accordingly, IC decreased the LPS‑induced serum levels of IL‑6, as well as intracellular IL‑6 production in B cells in vivo. However, these protective and inhibitory effects of IC were not observed in FcγRIIb‑/‑ mice. In conclusion, the present data demonstrated that FcγRIIb inhibited TLR4 signaling in B cells by activating Lyn phosphorylation and by inhibiting NF‑κΒ signaling. The present study elucidated the mechanism associated with the TLR4 and FcγRIIb cross‑talk in B cells.

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Copy and paste a formatted citation
Spandidos Publications style
Qian L, Chen W, Wang S, Liu Y, Jia X, Fu Y, Gong W and Tian F: FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells. Mol Med Rep 16: 5693-5698, 2017.
APA
Qian, L., Chen, W., Wang, S., Liu, Y., Jia, X., Fu, Y. ... Tian, F. (2017). FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells. Molecular Medicine Reports, 16, 5693-5698. https://doi.org/10.3892/mmr.2017.7269
MLA
Qian, L., Chen, W., Wang, S., Liu, Y., Jia, X., Fu, Y., Gong, W., Tian, F."FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells". Molecular Medicine Reports 16.4 (2017): 5693-5698.
Chicago
Qian, L., Chen, W., Wang, S., Liu, Y., Jia, X., Fu, Y., Gong, W., Tian, F."FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells". Molecular Medicine Reports 16, no. 4 (2017): 5693-5698. https://doi.org/10.3892/mmr.2017.7269
Copy and paste a formatted citation
x
Spandidos Publications style
Qian L, Chen W, Wang S, Liu Y, Jia X, Fu Y, Gong W and Tian F: FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells. Mol Med Rep 16: 5693-5698, 2017.
APA
Qian, L., Chen, W., Wang, S., Liu, Y., Jia, X., Fu, Y. ... Tian, F. (2017). FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells. Molecular Medicine Reports, 16, 5693-5698. https://doi.org/10.3892/mmr.2017.7269
MLA
Qian, L., Chen, W., Wang, S., Liu, Y., Jia, X., Fu, Y., Gong, W., Tian, F."FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells". Molecular Medicine Reports 16.4 (2017): 5693-5698.
Chicago
Qian, L., Chen, W., Wang, S., Liu, Y., Jia, X., Fu, Y., Gong, W., Tian, F."FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells". Molecular Medicine Reports 16, no. 4 (2017): 5693-5698. https://doi.org/10.3892/mmr.2017.7269
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