Open Access

Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats

  • Authors:
    • Young Jin Park
    • Young‑Rak Cho
    • Joa Sub Oh
    • Eun‑Kyung Ahn
  • View Affiliations

  • Published online on: August 21, 2017     https://doi.org/10.3892/mmr.2017.7296
  • Pages: 5303-5311
  • Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tribulus terrestris L. (T. terrestris) has been used as a traditional medicine for the treatment of diuretic, lithontriptic, edema and urinary infections. Previous studies have indicated that it is effective in improving inflammation by regulating tumor necrosis factor‑α (TNF)‑α, interleukin (IL)‑6, IL‑10, nitric oxide (NO) and cyclooxygenase (COX)‑2. However, the effects and mechanism of action of T. terrestris on osteoarthritis (OA) remain unknown. Therefore, the present study aimed to evaluate the effects of the ethanolic extract of T. terrestris (ETT) in a monosodium iodoacetate (MIA)‑induced OA animal model. OA was induced in LEW/SSNHSD rats by intra‑articular injection of MIA. Morphometric changes and parameters of the tibial trabecular bone were determined using micro‑computed tomography. The molecular mechanisms of ETT in OA were investigated using reverse transcription‑polymerase chain reaction, western blotting and gelatin zymogram analysis. Treatment with ETT attenuated MIA‑induced OA, and this effect was mediated by the downregulation of NO synthase 2, COX‑2, TNF‑α and IL‑6. Furthermore, the ETT‑mediated attenuation of OA was also dependent on the expression of matrix metalloproteinases‑2 and ‑9. The results of the current study indicate that further evaluation of the mechanisms underlying the attenuation of MIA‑induced OA by ETT are required, and may support the development of ETT as a potential therapeutic agent for the treatment of inflammatory diseases such as OA.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Park YJ, Cho YR, Oh JS and Ahn EK: Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. Mol Med Rep 16: 5303-5311, 2017
APA
Park, Y.J., Cho, Y., Oh, J.S., & Ahn, E. (2017). Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. Molecular Medicine Reports, 16, 5303-5311. https://doi.org/10.3892/mmr.2017.7296
MLA
Park, Y. J., Cho, Y., Oh, J. S., Ahn, E."Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats". Molecular Medicine Reports 16.4 (2017): 5303-5311.
Chicago
Park, Y. J., Cho, Y., Oh, J. S., Ahn, E."Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats". Molecular Medicine Reports 16, no. 4 (2017): 5303-5311. https://doi.org/10.3892/mmr.2017.7296