[Corrigendum] Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway

Yuan,Li; Zhou,Mengmeng; Huang,Dawei; Wasan,Harpreet S.; Zhang,Kai; Sun,Leitao; Huang,Hong; Ma,Shenglin; Shen,Minhe; Ruan,Shanming

doi:10.3892/mmr.2022.12870

December-2022 Volume 26 Issue 6

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December-2022 Volume 26 Issue 6

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Correction Open Access

[Corrigendum] Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway

Authors:
- Li Yuan
- Mengmeng Zhou
- Dawei Huang
- Harpreet S. Wasan
- Kai Zhang
- Leitao Sun
- Hong Huang
- Shenglin Ma
- Minhe Shen
- Shanming Ruan
View Affiliations / Copyright

Affiliations: The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Traditional Chinese Medicine, The First People's Hospital of Quzhou, Quzhou, Zhejiang 324000, P.R. China, Department of Chinese Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Cancer Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London W12 0HS, UK, Teaching and Research Section of Prescription, Basic Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Medical Oncology, The Fourth Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China

Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 354
|
Published online on: October 10, 2022

https://doi.org/10.3892/mmr.2022.12870
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Mol Med Rep 20: [Related article:] 2783–2795, 2019; DOI: 10.3892/mmr.2019.10528

Subsequently to the publication of the above article, an interested reader drew to the authors’ attention that the Nc-control and si-AKT1-control data panels featured in Fig. 4A for the SW480 Transwell assay experiments on p. 2788 appeared to contain overlapping data, such that the data, which were intended to show the results from experiments performed under different experimental conditions, may have been derived from the same original source. Furthermore, in Fig. 5 on p. 2789, there appeared to be some overlapping data comparing the AKT1 western blotting data with the p-AKT1 data, and the same data also appeared in Fig. 4D for the p-AKT1 data presented there.

Figure 4.

Resveratrol inhibits the migration and invasion of SW480 and SW620 cells in vitro. Cells were subjected to the same drug treatments as those used in the scratch wound healing assay. (A and B) Transwell migration assay revealing the migration of SW480 and SW620 cells subjected to various treatments. (C and D) Transwell invasion assay revealing the invasion of SW480 and SW620 cells subjected to various treatments. The number of migrated and invaded cells passing through the membrane in the NC-resveratrol and si-AKT1-control groups was significantly lower than that in the NC-control group. There was no significant difference between the number of migrated and invaded cells passing through the membrane in the si-AKT1-control and si-AKT1-resveratrol groups. *P<0.05, ***P<0.001, and NS (P>0.05) compared with the respective control; n=9. These data were evaluated by one-way ANOVA. NC, negative control; si-, small interfering-; NS, not significant.

Figure 5.

Resveratrol reverses EMT in colon cancer cells via regulation of the AKT/GSK-3β/Snail signaling pathway in vitro (1=NC-control, 2=NC-resveratrol, 3=si-AKT1-control, 4=si-AKT1-resveratrol group). Cells were subjected to the same drug treatments as those used in the scratch wound healing assay. Expression of E-cadherin, N-cadherin, p-AKT1, AKT1, p-GSK-3β, GSK-3β, and Snail was evaluated in (A-C) SW480 cells and (D-F) SW620 cells subjected to various treatments via western blotting. In comparison with that in the NC-control group, E-cadherin expression was upregulated in the NC-resveratrol and si-AKT1-control groups, whereas the expression of N-cadherin, p-AKT, p-GSK-3β, and Snail was downregulated. However, there was no difference in the expression of these proteins between the si-AKT1-resveratrol and si-AKT1-control groups. *P<0.05, **P<0.01, ***P<0.001, and NS (P>0.05) compared with the respective control; n=3. These data were evaluated by one-way ANOVA. EMT, epithelial-mesenchymal transition; GSK, glycogen synthase kinase; p-, phosphor-; NC, negative control; si-, small interfering-; NS, not significant.

The authors have re-examined their original data, and have realized that these figures were assembled incorrectly; essentially, the si-AKT1-control data panel was selected incorrectly for Fig. 4A, and the authors were able to retrieve the original data for the western blots presented in Fig. 5. The corrected versions of Figs. 4 and 5 are shown on the next page. The authors confirm that these errors did not have any major impact on the conclusions reported in their paper, and are grateful to the Editor of Molecular Medicine Reports for allowing them this opportunity to publish a Corrigendum. Furthermore, the authors apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Resveratrol inhibits the invasion and metastasis of colon cancer through reversal of epithelial‑mesenchymal transition via the AKT/GSK‑3β/Snail signaling pathway

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