Open Access

Carnosine and bone (Review)

  • Authors:
    • Hao Yang
    • Xiaoli Hou
    • Lei Xing
    • Faming Tian
  • View Affiliations

  • Published online on: November 17, 2022     https://doi.org/10.3892/mmr.2022.12899
  • Article Number: 12
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Carnosine is a vital endogenous dipeptide that has anti‑inflammatory, antiaging, anti‑crosslinking, antitumor and immune regulatory effects. Numerous cell and animal model studies have proved that carnosine and its compounds promote the proliferation and differentiation of osteoblasts, inhibit osteoclasts and protect chondrocytes. They also regulate the cell cycle of bone progenitor cells and the differentiation of bone marrow mesenchymal stem cells, accelerate fracture healing, delay bone tumor development and ameliorate osteopenia induced by estrogen deficiency or disuse. The correlations between carnosine and activation signal molecules, pluripotent differentiation of bone marrow mesenchymal stem cells and interaction between bone cells are unclear. However, studies have proved that carnosine and its compounds have benefits in preventing and treating specific bone diseases. This makes them potential agents for the treatment of osteoporosis and bone tumors. The present review summarized the existing research on carnosine and its compounds in bone cells and tissue. It focused on the physiological function of carnosine and its compounds in the bone and their effect on bone metabolism‑related diseases, thus providing support for developing new strategies for targeted therapy.

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January-2023
Volume 27 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang H, Hou X, Xing L and Tian F: Carnosine and bone (Review). Mol Med Rep 27: 12, 2023
APA
Yang, H., Hou, X., Xing, L., & Tian, F. (2023). Carnosine and bone (Review). Molecular Medicine Reports, 27, 12. https://doi.org/10.3892/mmr.2022.12899
MLA
Yang, H., Hou, X., Xing, L., Tian, F."Carnosine and bone (Review)". Molecular Medicine Reports 27.1 (2023): 12.
Chicago
Yang, H., Hou, X., Xing, L., Tian, F."Carnosine and bone (Review)". Molecular Medicine Reports 27, no. 1 (2023): 12. https://doi.org/10.3892/mmr.2022.12899