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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-2026 Volume 33 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Review Open Access

Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)

  • Authors:
    • Jinjin Yu
    • Huiheng Qu
    • Weicheng Xu
    • Yiming Fang
    • Nan Wang
    • Wei Shi

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, Jiangsu 214000, P.R. China, Department of General Surgery, Jiangnan University Medical Center, Jiangnan University, Wuxi, Jiangsu 214002, P.R. China, Department of Ophthalmology, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, The First Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210004, P.R. China, Department of Cancer Biology, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston‑Salem, NC 27157, USA
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 126
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    Published online on: March 4, 2026
       https://doi.org/10.3892/mmr.2026.13836
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Abstract

Glycyrrhizic acid (GL), a natural extract derived from licorice, has shown notable therapeutic potential across various diseases through complex mechanisms involving key signaling pathways. The present review systematically summarized the primary biological actions of GL, highlighting its role as an inhibitor of high‑mobility group box‑1 and regulator of multiple notable pathways, including the nuclear factor‑κB, phosphoinositide 3‑kinase/protein kinase B, mitogen‑activated protein kinase, Janus kinase/signal transducer and activator of transcription and pyroptosis‑related pathways. GL effectively modulates innate and adaptive immune responses, reduces inflammation and exhibits protective effects against liver injury. In oncology, GL has demonstrated anti‑proliferative and pro‑apoptotic effects by interacting with the tumor microenvironment, suppressing angiogenesis and enhancing chemotherapeutic efficacy as an adjuvant therapy. By synthesizing previous research advancements that elucidate the multifaceted biological mechanisms of GL, the present review aimed to provide a comprehensive foundation for future translational research.

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Copy and paste a formatted citation
Spandidos Publications style
Yu J, Qu H, Xu W, Fang Y, Wang N and Shi W: Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review). Mol Med Rep 33: 126, 2026.
APA
Yu, J., Qu, H., Xu, W., Fang, Y., Wang, N., & Shi, W. (2026). Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review). Molecular Medicine Reports, 33, 126. https://doi.org/10.3892/mmr.2026.13836
MLA
Yu, J., Qu, H., Xu, W., Fang, Y., Wang, N., Shi, W."Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)". Molecular Medicine Reports 33.5 (2026): 126.
Chicago
Yu, J., Qu, H., Xu, W., Fang, Y., Wang, N., Shi, W."Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)". Molecular Medicine Reports 33, no. 5 (2026): 126. https://doi.org/10.3892/mmr.2026.13836
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Qu H, Xu W, Fang Y, Wang N and Shi W: Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review). Mol Med Rep 33: 126, 2026.
APA
Yu, J., Qu, H., Xu, W., Fang, Y., Wang, N., & Shi, W. (2026). Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review). Molecular Medicine Reports, 33, 126. https://doi.org/10.3892/mmr.2026.13836
MLA
Yu, J., Qu, H., Xu, W., Fang, Y., Wang, N., Shi, W."Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)". Molecular Medicine Reports 33.5 (2026): 126.
Chicago
Yu, J., Qu, H., Xu, W., Fang, Y., Wang, N., Shi, W."Mechanisms and therapeutic potential of glycyrrhizic acid: Insights into key signaling pathways and disease modulation (Review)". Molecular Medicine Reports 33, no. 5 (2026): 126. https://doi.org/10.3892/mmr.2026.13836
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