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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-2026 Volume 33 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Review Open Access

Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)

  • Authors:
    • Hong Wang
    • Hongyuan Lv
    • Xiaolin Zhang
    • Meifang Liu
    • Liyuan Wang
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 151
    |
    Published online on: March 26, 2026
       https://doi.org/10.3892/mmr.2026.13861
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Abstract

Obesity has become a global epidemic and a notable trigger for numerous chronic diseases, including insulin resistance, type II diabetes, cardiovascular disease, non‑alcoholic fatty liver disease and cancer, which is characterized by chronic low‑grade inflammation in the adipose tissue. Traditionally, adipose tissue macrophages were considered the central drivers of obesity‑associated inflammation; however, studies have revealed that B cells play a notable role in adipose tissue inflammation and metabolic homeostasis. The present review systematically elaborates on the distribution and functions of B cells within adipose tissue, with a focus on the dynamic changes in B cell subsets during the progression of obesity, the mechanisms in promoting metabolic diseases, and the potential applications and challenges of targeting B cells for the treatment of obesity‑related metabolic disorders, in order to provide new insights into the mechanistic understanding and therapy of obesity and its associated metabolic diseases.

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Lv H, Zhang X, Liu M and Wang L: Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review). Mol Med Rep 33: 151, 2026.
APA
Wang, H., Lv, H., Zhang, X., Liu, M., & Wang, L. (2026). Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review). Molecular Medicine Reports, 33, 151. https://doi.org/10.3892/mmr.2026.13861
MLA
Wang, H., Lv, H., Zhang, X., Liu, M., Wang, L."Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)". Molecular Medicine Reports 33.5 (2026): 151.
Chicago
Wang, H., Lv, H., Zhang, X., Liu, M., Wang, L."Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)". Molecular Medicine Reports 33, no. 5 (2026): 151. https://doi.org/10.3892/mmr.2026.13861
Copy and paste a formatted citation
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Spandidos Publications style
Wang H, Lv H, Zhang X, Liu M and Wang L: Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review). Mol Med Rep 33: 151, 2026.
APA
Wang, H., Lv, H., Zhang, X., Liu, M., & Wang, L. (2026). Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review). Molecular Medicine Reports, 33, 151. https://doi.org/10.3892/mmr.2026.13861
MLA
Wang, H., Lv, H., Zhang, X., Liu, M., Wang, L."Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)". Molecular Medicine Reports 33.5 (2026): 151.
Chicago
Wang, H., Lv, H., Zhang, X., Liu, M., Wang, L."Mechanism and therapeutic prospects of adipose tissue B lymphocytes in obesity and obesity‑associated metabolic diseases (Review)". Molecular Medicine Reports 33, no. 5 (2026): 151. https://doi.org/10.3892/mmr.2026.13861
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