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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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August-2026 Volume 34 Issue 2

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Article

Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells

  • Authors:
    • Qing Deng
    • Xiujuan Liu
    • Dan Wen
    • Yuhua Cheng
    • Qing Zhao
    • Yu Wang
    • Yu Xiang
    • Qinkai Chen
    • Jinlei Lv

  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Nephrology, The 908th Hospital of the People's Liberation Army Joint Logistics Support Force, The Great Wall Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Nephrology, Jiujiang University Affiliated Hospital, Jiujiang, Jiangxi 332001, P.R. China
  • Article Number: 230
    |
    Published online on: June 17, 2026
       https://doi.org/10.3892/mmr.2026.13940
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Abstract

Diabetic kidney disease is a frequent complication of diabetes and the predominant cause of end‑stage renal disease. However, the pathogenesis of diabetic kidney disease has not been fully elucidated. HK‑2 cells cultured in vitro were randomly divided into control, high glucose, high glucose + MCC950 and high glucose + irbesartan groups. The present study detected the mRNA and protein expression of NLRP3, caspase‑1, NF‑κB p65, α‑SMA, vimentin and N‑cadherin using reverse transcription‑quantitative PCR and western blotting. The present study also detected the protein expression of vimentin using immunocyte fluorescence. High glucose (40 mM) significantly increased the mRNA and protein levels of NLRP3, NF‑κB p65, caspase‑1 and epithelial‑mesenchymal transition (EMT) markers; these effects were attenuated by MCC950 and irbesartan administration. These results indicated that high glucose stimulation upregulated the expression of NLRP3 in HK‑2 cells and promoted the expression of EMT‑associated factors. Irbesartan inhibited the activation of the NLRP3 inflammasome and downregulated the expression of EMT‑related factors, which provided a basis for potential new strategies for the treatment of diabetic nephropathy.

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Copy and paste a formatted citation
Spandidos Publications style
Deng Q, Liu X, Wen D, Cheng Y, Zhao Q, Wang Y, Xiang Y, Chen Q and Lv J: Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells. Mol Med Rep 34: 230, 2026.
APA
Deng, Q., Liu, X., Wen, D., Cheng, Y., Zhao, Q., Wang, Y. ... Lv, J. (2026). Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells. Molecular Medicine Reports, 34, 230. https://doi.org/10.3892/mmr.2026.13940
MLA
Deng, Q., Liu, X., Wen, D., Cheng, Y., Zhao, Q., Wang, Y., Xiang, Y., Chen, Q., Lv, J."Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells". Molecular Medicine Reports 34.2 (2026): 230.
Chicago
Deng, Q., Liu, X., Wen, D., Cheng, Y., Zhao, Q., Wang, Y., Xiang, Y., Chen, Q., Lv, J."Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells". Molecular Medicine Reports 34, no. 2 (2026): 230. https://doi.org/10.3892/mmr.2026.13940
Copy and paste a formatted citation
x
Spandidos Publications style
Deng Q, Liu X, Wen D, Cheng Y, Zhao Q, Wang Y, Xiang Y, Chen Q and Lv J: Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells. Mol Med Rep 34: 230, 2026.
APA
Deng, Q., Liu, X., Wen, D., Cheng, Y., Zhao, Q., Wang, Y. ... Lv, J. (2026). Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells. Molecular Medicine Reports, 34, 230. https://doi.org/10.3892/mmr.2026.13940
MLA
Deng, Q., Liu, X., Wen, D., Cheng, Y., Zhao, Q., Wang, Y., Xiang, Y., Chen, Q., Lv, J."Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells". Molecular Medicine Reports 34.2 (2026): 230.
Chicago
Deng, Q., Liu, X., Wen, D., Cheng, Y., Zhao, Q., Wang, Y., Xiang, Y., Chen, Q., Lv, J."Irbesartan ameliorates high‑glucose‑induced epithelial‑mesenchymal transition by downregulating the expression of NLRP3 in HK‑2 cells". Molecular Medicine Reports 34, no. 2 (2026): 230. https://doi.org/10.3892/mmr.2026.13940
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