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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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August-2026 Volume 34 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)

  • Authors:
    • Xiaokang Wang
    • Qiwen Tan
    • Jingcheng Xu
    • Yunlin Yang
    • Haoyue Huang
    • Xiaomei Teng
    • Weihua Wu

  • View Affiliations / Copyright

    Affiliations: Center of Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 232
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    Published online on: June 18, 2026
       https://doi.org/10.3892/mmr.2026.13942
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Abstract

Thoracic aortic aneurysm and dissection (TAAD) is a life‑threatening disease with an insidious onset and a largely elusive pathogenesis. Hereditary TAAD (HTAD) can be classified into syndromic forms, including Marfan syndrome, Loeys‑Dietz syndrome and vascular Ehlers‑Danlos syndrome and non‑syndromic forms, including familial TAAD and bicuspid aortic valve‑associated TAAD. Current evidence suggests that HTAD development shares several core mechanisms, including extracellular matrix disruption, dysregulated transforming growth factor‑β signaling, vascular smooth muscle cell dysfunction and, in the case of bicuspid aortic valve, abnormal hemodynamic stress. The present review summarizes the major genes and molecular pathways involved in HTAD and discusses their contributions to disease progression. Elucidating the underlying mechanisms associated with HTAD may facilitate risk assessment and the development of targeted therapies.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Tan Q, Xu J, Yang Y, Huang H, Teng X and Wu W: Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review). Mol Med Rep 34: 232, 2026.
APA
Wang, X., Tan, Q., Xu, J., Yang, Y., Huang, H., Teng, X., & Wu, W. (2026). Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review). Molecular Medicine Reports, 34, 232. https://doi.org/10.3892/mmr.2026.13942
MLA
Wang, X., Tan, Q., Xu, J., Yang, Y., Huang, H., Teng, X., Wu, W."Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)". Molecular Medicine Reports 34.2 (2026): 232.
Chicago
Wang, X., Tan, Q., Xu, J., Yang, Y., Huang, H., Teng, X., Wu, W."Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)". Molecular Medicine Reports 34, no. 2 (2026): 232. https://doi.org/10.3892/mmr.2026.13942
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Tan Q, Xu J, Yang Y, Huang H, Teng X and Wu W: Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review). Mol Med Rep 34: 232, 2026.
APA
Wang, X., Tan, Q., Xu, J., Yang, Y., Huang, H., Teng, X., & Wu, W. (2026). Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review). Molecular Medicine Reports, 34, 232. https://doi.org/10.3892/mmr.2026.13942
MLA
Wang, X., Tan, Q., Xu, J., Yang, Y., Huang, H., Teng, X., Wu, W."Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)". Molecular Medicine Reports 34.2 (2026): 232.
Chicago
Wang, X., Tan, Q., Xu, J., Yang, Y., Huang, H., Teng, X., Wu, W."Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review)". Molecular Medicine Reports 34, no. 2 (2026): 232. https://doi.org/10.3892/mmr.2026.13942
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