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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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October-2026 Volume 34 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)

  • Authors:
    • Rongtou Huang
    • Danning Mo
    • Huitian Huang
    • Minmin Zhang
    • Wenhong Yu
    • Buqing Cao
  • View Affiliations / Copyright

    Affiliations: Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530200, P.R. China, Department of Laboratory Medicine, Konggang Hospital of Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Chongzuo, Guangxi Zhuang Autonomous Region 532100, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 266
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    Published online on: July 29, 2026
       https://doi.org/10.3892/mmr.2026.13977
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Abstract

The chemokine‑like factor (CKLF)‑like MARVEL transmembrane domain‑containing (CMTM) family belongs to the human CKLF gene superfamily, which comprises CKLF and CMTM1‑8. Among its members, CMTM6 encodes a protein exhibiting structural and functional characteristics that lie between classical chemokines and tetraspanins. CMTM6 is expressed in several normal tissues, including those of the immune, reproductive and nervous systems. Notably, its expression is frequently upregulated across a broad spectrum of tumors including, but not limited to, carcinomas of the lung, liver and gastrointestinal tract. CMTM6 contributes to tumor proliferation, invasion and metastasis by inhibiting immune responses, facilitating immune evasion and inducing epithelial‑mesenchymal transition, thereby influencing patient prognosis and survival outcomes. The present review systematically summarizes the molecular functions, mechanisms of action, disease‑related expression patterns and clinical translational applications of CMTM6, aiming to provide novel clinical insights and to guide the development of CMTM6‑targeted therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Huang R, Mo D, Huang H, Zhang M, Yu W and Cao B: Role of CMTM6 in disease pathogenesis and clinical translation potential (Review). Mol Med Rep 34: 266, 2026.
APA
Huang, R., Mo, D., Huang, H., Zhang, M., Yu, W., & Cao, B. (2026). Role of CMTM6 in disease pathogenesis and clinical translation potential (Review). Molecular Medicine Reports, 34, 266. https://doi.org/10.3892/mmr.2026.13977
MLA
Huang, R., Mo, D., Huang, H., Zhang, M., Yu, W., Cao, B."Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)". Molecular Medicine Reports 34.4 (2026): 266.
Chicago
Huang, R., Mo, D., Huang, H., Zhang, M., Yu, W., Cao, B."Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)". Molecular Medicine Reports 34, no. 4 (2026): 266. https://doi.org/10.3892/mmr.2026.13977
Copy and paste a formatted citation
x
Spandidos Publications style
Huang R, Mo D, Huang H, Zhang M, Yu W and Cao B: Role of CMTM6 in disease pathogenesis and clinical translation potential (Review). Mol Med Rep 34: 266, 2026.
APA
Huang, R., Mo, D., Huang, H., Zhang, M., Yu, W., & Cao, B. (2026). Role of CMTM6 in disease pathogenesis and clinical translation potential (Review). Molecular Medicine Reports, 34, 266. https://doi.org/10.3892/mmr.2026.13977
MLA
Huang, R., Mo, D., Huang, H., Zhang, M., Yu, W., Cao, B."Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)". Molecular Medicine Reports 34.4 (2026): 266.
Chicago
Huang, R., Mo, D., Huang, H., Zhang, M., Yu, W., Cao, B."Role of CMTM6 in disease pathogenesis and clinical translation potential (Review)". Molecular Medicine Reports 34, no. 4 (2026): 266. https://doi.org/10.3892/mmr.2026.13977
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