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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-2026 Volume 34 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)

  • Authors:
    • Mary-Lyn Eichhorn
    • Anna M. Dmitrieva
    • Lydia Meder

  • View Affiliations / Copyright

    Affiliations: Department of Experimental Medicine 1, Cell Plasticity at The Tumor‑Host‑Interface, Faculty of Medicine, Friedrich‑Alexander University Erlangen‑Nürnberg, D‑91054 Erlangen, Germany
    Copyright: © Eichhorn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 300
    |
    Published online on: September 8, 2026
       https://doi.org/10.3892/mmr.2026.14011
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Abstract

Squamous cell carcinoma (SCC) comprises a heterogeneous group of malignancies with distinct molecular characteristics, clinical behavior and therapeutic responses, highlighting the need for personalized treatment strategies. Circadian rhythms regulate fundamental physiological processes, including cell proliferation, metabolism, DNA repair and immune function, and emerging evidence suggests that circadian regulation may influence pathways relevant to SCC biology and treatment response. This review summarizes current knowledge on the role of circadian regulation in SCC, with particular emphasis on lung SCC, focusing on core clock genes, their interactions with oncogenic and immune‑related pathways, and their therapeutic implications. We discuss current evidence supporting chronotherapy as a potential component of personalized SCC treatment while addressing important limitations, including the predominance of preclinical studies, limited SCC‑specific clinical evidence and extrapolation from other tumor types. Finally, we outline key research priorities for translating circadian biology into clinical SCC management.

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Copy and paste a formatted citation
Spandidos Publications style
Eichhorn M, Dmitrieva AM and Meder L: Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review). Mol Med Rep 34: 300, 2026.
APA
Eichhorn, M., Dmitrieva, A.M., & Meder, L. (2026). Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review). Molecular Medicine Reports, 34, 300. https://doi.org/10.3892/mmr.2026.14011
MLA
Eichhorn, M., Dmitrieva, A. M., Meder, L."Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)". Molecular Medicine Reports 34.5 (2026): 300.
Chicago
Eichhorn, M., Dmitrieva, A. M., Meder, L."Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)". Molecular Medicine Reports 34, no. 5 (2026): 300. https://doi.org/10.3892/mmr.2026.14011
Copy and paste a formatted citation
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Spandidos Publications style
Eichhorn M, Dmitrieva AM and Meder L: Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review). Mol Med Rep 34: 300, 2026.
APA
Eichhorn, M., Dmitrieva, A.M., & Meder, L. (2026). Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review). Molecular Medicine Reports, 34, 300. https://doi.org/10.3892/mmr.2026.14011
MLA
Eichhorn, M., Dmitrieva, A. M., Meder, L."Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)". Molecular Medicine Reports 34.5 (2026): 300.
Chicago
Eichhorn, M., Dmitrieva, A. M., Meder, L."Role of the circadian rhythm in squamous cell carcinoma: From molecular mechanism to therapy (Review)". Molecular Medicine Reports 34, no. 5 (2026): 300. https://doi.org/10.3892/mmr.2026.14011
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