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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-2026 Volume 34 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Review Open Access

Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)

  • Authors:
    • Changshun Chen
    • Xingxi Hu
    • Sixing Wei
    • Yongcheng Deng
    • Qinggang Zhao
    • Ge Chen
    • Zhong Cheng
    • Jianhua Ji
    • Jinyi Gu

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics and Trauma Surgery, Affiliated Hospital of Yunnan University, Kunming, Yunnan 650032, P.R. China, Clinical Laboratory, Affiliated Hospital of Yunnan University, Kunming, Yunnan 650032, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 312
    |
    Published online on: September 15, 2026
       https://doi.org/10.3892/mmr.2026.14023
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Abstract

Osteoporosis (OP) is a multifactorial skeletal disorder characterized by progressive bone loss, microarchitectural deterioration and an increased risk of fragility fractures resulting from disrupted bone remodeling. Integrin αVβ3 functions as an important regulator of bone homeostasis by coordinating bone cell‑extracellular matrix interactions, mechanotransduction and intracellular signaling across multiple bone cell populations. Through context‑dependent actions in osteoclasts, osteoblasts, osteocytes, endothelial cells and immune cells, integrin αVβ3 influences osteoclast adhesion and bone resorption, osteoblast differentiation, angiogenesis, inflammatory responses, and estrogen‑associated skeletal remodeling. These diverse functions position integrin αVβ3 at the interface of the multiple signaling pathways involved in maintaining bone‑metabolic homeostasis. The present review summarizes current evidence regarding the molecular mechanisms underlying the integrin αVβ3‑mediated regulation of bone remodeling, discusses the cell‑specific and microenvironment‑dependent functions of integrin αVβ3 in OP pathogenesis, and critically evaluates the challenges and future directions for translating integrin αVβ3‑targeted strategies into clinical applications against OP.

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Copy and paste a formatted citation
Spandidos Publications style
Chen C, Hu X, Wei S, Deng Y, Zhao Q, Chen G, Cheng Z, Ji J and Gu J: Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review). Mol Med Rep 34: 312, 2026.
APA
Chen, C., Hu, X., Wei, S., Deng, Y., Zhao, Q., Chen, G. ... Gu, J. (2026). Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review). Molecular Medicine Reports, 34, 312. https://doi.org/10.3892/mmr.2026.14023
MLA
Chen, C., Hu, X., Wei, S., Deng, Y., Zhao, Q., Chen, G., Cheng, Z., Ji, J., Gu, J."Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)". Molecular Medicine Reports 34.5 (2026): 312.
Chicago
Chen, C., Hu, X., Wei, S., Deng, Y., Zhao, Q., Chen, G., Cheng, Z., Ji, J., Gu, J."Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)". Molecular Medicine Reports 34, no. 5 (2026): 312. https://doi.org/10.3892/mmr.2026.14023
Copy and paste a formatted citation
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Spandidos Publications style
Chen C, Hu X, Wei S, Deng Y, Zhao Q, Chen G, Cheng Z, Ji J and Gu J: Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review). Mol Med Rep 34: 312, 2026.
APA
Chen, C., Hu, X., Wei, S., Deng, Y., Zhao, Q., Chen, G. ... Gu, J. (2026). Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review). Molecular Medicine Reports, 34, 312. https://doi.org/10.3892/mmr.2026.14023
MLA
Chen, C., Hu, X., Wei, S., Deng, Y., Zhao, Q., Chen, G., Cheng, Z., Ji, J., Gu, J."Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)". Molecular Medicine Reports 34.5 (2026): 312.
Chicago
Chen, C., Hu, X., Wei, S., Deng, Y., Zhao, Q., Chen, G., Cheng, Z., Ji, J., Gu, J."Integrin αVβ3 as a context‑dependent regulator of bone homeostasis: Insights into osteoporosis pathogenesis and therapeutic targeting (Review)". Molecular Medicine Reports 34, no. 5 (2026): 312. https://doi.org/10.3892/mmr.2026.14023
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