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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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September-October 2008 Volume 1 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization

  • Authors:
    • Debora Duò
    • Chiara Ghimenti
    • Paola Migliora
    • Maria Cristina Pavanelli
    • Luca Mastracci
    • Giovanni Angeli

  • View Affiliations / Copyright

    Affiliations: Unit of Pathological Anatomy, S. Andrea Hospital, I-13100 Vercelli, Italy
  • Pages: 673-677
    |
    Published online on: September 1, 2008
       https://doi.org/10.3892/mmr_00000011
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Abstract

Human papillomavirus (HPV) infection is known to play a fundamental role in cervical and other ano-genital human cancers. The recent identification of HPVs in human breast tumors and the immortalization of normal breast cancer cells by HPV high risk types 16 and 18 suggest that the virus could be implicated in the pathogenesis of human mammary tumors. In this study, we investigated the presence of high and low risk HPV genotypes in 30 human breast cancers of different histotypes by PCR with specific HPV primers (MY09/MY11 and GP5+/GP6+) and by line probe assay (LiPA) reverse hybridization. Since the only positive case (untypable HPVX+) was a papillary breast carcinoma, a rare tumor variant, we analyzed a further cohort of 32 papillary cancers and found one additional HPV DNA-positive case (HPV66+). Our results suggest that HPV infection is not significant in mammary tumorigenesis, with the exception of particular tumor histotypes, such as papillary cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Duò D, Ghimenti C, Migliora P, Pavanelli MC, Mastracci L and Angeli G: Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization. Mol Med Rep 1: 673-677, 2008.
APA
Duò, D., Ghimenti, C., Migliora, P., Pavanelli, M.C., Mastracci, L., & Angeli, G. (2008). Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization. Molecular Medicine Reports, 1, 673-677. https://doi.org/10.3892/mmr_00000011
MLA
Duò, D., Ghimenti, C., Migliora, P., Pavanelli, M. C., Mastracci, L., Angeli, G."Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization". Molecular Medicine Reports 1.5 (2008): 673-677.
Chicago
Duò, D., Ghimenti, C., Migliora, P., Pavanelli, M. C., Mastracci, L., Angeli, G."Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization". Molecular Medicine Reports 1, no. 5 (2008): 673-677. https://doi.org/10.3892/mmr_00000011
Copy and paste a formatted citation
x
Spandidos Publications style
Duò D, Ghimenti C, Migliora P, Pavanelli MC, Mastracci L and Angeli G: Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization. Mol Med Rep 1: 673-677, 2008.
APA
Duò, D., Ghimenti, C., Migliora, P., Pavanelli, M.C., Mastracci, L., & Angeli, G. (2008). Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization. Molecular Medicine Reports, 1, 673-677. https://doi.org/10.3892/mmr_00000011
MLA
Duò, D., Ghimenti, C., Migliora, P., Pavanelli, M. C., Mastracci, L., Angeli, G."Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization". Molecular Medicine Reports 1.5 (2008): 673-677.
Chicago
Duò, D., Ghimenti, C., Migliora, P., Pavanelli, M. C., Mastracci, L., Angeli, G."Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization". Molecular Medicine Reports 1, no. 5 (2008): 673-677. https://doi.org/10.3892/mmr_00000011
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