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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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November-December 2008 Volume 1 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2008 Volume 1 Issue 6

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Article

Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast

  • Authors:
    • Angela F. Logullo
    • Suely Nonogaki
    • Maria Do Socorro Maciel
    • Mário Mourão-Neto
    • Fernando Augusto Soares

  • View Affiliations / Copyright

    Affiliations: Universidade Federal de São Paulo - Escola Paulista de Medicina (Unifesp-EPM), CEP 04023-062 São Paulo (SP), Brazil. aflw@terra.com.br
  • Pages: 857-861
    |
    Published online on: November 1, 2008
       https://doi.org/10.3892/mmr_00000041
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Abstract

The CD117 protein is a tyrosine-kinase receptor encoded by the c-kit gene that frequently bears activating mutations in gastrointestinal tumors. Conflicting findings regarding CD117 expression in other stromal tumors, including phyllodes tumors (PTs), have been reported in the literature. The purpose of this study was to evaluate c-kit expression in the stroma and epithelia of fibroepithelial breast tumors and its correlation with clinical pathological variables. Ninety-six fibroepithelial tumors of the breast, including 14 fibroadenomas (FAs), 12 juvenile FAs and 70 PTs, were classified according to stromal cellularity, atypia, epithelial hyperplasia, mitosis and borders into 45 benign (PTB), 17 borderline (PTBL) and 8 malignant (PTM) tumors. CD117 expression was identified in the stromal component in only two cases of PTBL. Overall, 38 cases (39.6%) showed positive CD117 in the epithelial component, including 20 FAs (10 regular, 10 juvenile) and 18 PTs (11 PTBs and 8 PTBLs). Other cases, including all PTMs, 6 FAs (4 regular, 2 juvenile), 34 PTBs and 10 PTBLs, showed no positivity in the epithelial component. Expression of c-kit did not correlate with diagnosis or malignancy (p>0.05). In conclusion, c-kit is expressed more often in the epithelial than in the stromal component in fibroepithelial tumors of the breast, and is associated with benign lesions.

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Copy and paste a formatted citation
Spandidos Publications style
Logullo AF, Nonogaki S, Do Socorro Maciel M, Mourão-Neto M and Soares FA: Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast. Mol Med Rep 1: 857-861, 2008.
APA
Logullo, A.F., Nonogaki, S., Do Socorro Maciel, M., Mourão-Neto, M., & Soares, F.A. (2008). Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast. Molecular Medicine Reports, 1, 857-861. https://doi.org/10.3892/mmr_00000041
MLA
Logullo, A. F., Nonogaki, S., Do Socorro Maciel, M., Mourão-Neto, M., Soares, F. A."Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast". Molecular Medicine Reports 1.6 (2008): 857-861.
Chicago
Logullo, A. F., Nonogaki, S., Do Socorro Maciel, M., Mourão-Neto, M., Soares, F. A."Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast". Molecular Medicine Reports 1, no. 6 (2008): 857-861. https://doi.org/10.3892/mmr_00000041
Copy and paste a formatted citation
x
Spandidos Publications style
Logullo AF, Nonogaki S, Do Socorro Maciel M, Mourão-Neto M and Soares FA: Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast. Mol Med Rep 1: 857-861, 2008.
APA
Logullo, A.F., Nonogaki, S., Do Socorro Maciel, M., Mourão-Neto, M., & Soares, F.A. (2008). Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast. Molecular Medicine Reports, 1, 857-861. https://doi.org/10.3892/mmr_00000041
MLA
Logullo, A. F., Nonogaki, S., Do Socorro Maciel, M., Mourão-Neto, M., Soares, F. A."Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast". Molecular Medicine Reports 1.6 (2008): 857-861.
Chicago
Logullo, A. F., Nonogaki, S., Do Socorro Maciel, M., Mourão-Neto, M., Soares, F. A."Stromal and epithelial cells react differentially to c-kit in fibroepithelial tumors of the breast". Molecular Medicine Reports 1, no. 6 (2008): 857-861. https://doi.org/10.3892/mmr_00000041
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