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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2009 Volume 2 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2009 Volume 2 Issue 1

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Article

Roles of high-mobility group box 1 in murine experimental colitis

  • Authors:
    • Hiroshi Yamasaki
    • Keiichi Mitsuyama
    • Junya Masuda
    • Kotaro Kuwaki
    • Hidetoshi Takedatsu
    • Gen Sugiyama
    • Shingo Yamada
    • Michio Sata

  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan
  • Pages: 23-27
    |
    Published online on: January 1, 2009
       https://doi.org/10.3892/mmr_00000056
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Abstract

High-mobility group box 1 (HMGB1) plays a role in inflammatory and immune-mediated diseases. This study investigated the role of HMGB1 in colonic inflammation. Colitis was induced by orally feeding mice 4.5% dextran sulfate sodium (DSS) for up to 7 days. Mice were sacrificed on days 0, 3, 7 and 10, and the colon harvested for the measurement of HMGB1 and pro-inflammatory cytokines. To block HMGB1 induction, an anti-HMGB1 antibody was administered intraperitoneally 2 h before or 3 days after the induction of colitis, and disease severity was assessed by clinical and histological scoring. The colonic levels of tumor necrosis factor-α and interleukin-1β were elevated in relation to disease severity. The level of HMGB1 increased more slowly than that of the cytokines. Immunohistochemical study of the colons showed that the tissues of mice treated with DSS had a higher expression of HMGB1 and its receptor - the receptor for advanced glycation end products - than normal controls, especially in inflammatory infiltrates. The anti-HMGB1 antibody ameliorated tissue damage. In conclusion, HMGB1 is an important mediator of colonic inflammation, and suppression of this protein partially protects against colonic inflammation.

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Copy and paste a formatted citation
Spandidos Publications style
Yamasaki H, Mitsuyama K, Masuda J, Kuwaki K, Takedatsu H, Sugiyama G, Yamada S and Sata M: Roles of high-mobility group box 1 in murine experimental colitis. Mol Med Rep 2: 23-27, 2009.
APA
Yamasaki, H., Mitsuyama, K., Masuda, J., Kuwaki, K., Takedatsu, H., Sugiyama, G. ... Sata, M. (2009). Roles of high-mobility group box 1 in murine experimental colitis. Molecular Medicine Reports, 2, 23-27. https://doi.org/10.3892/mmr_00000056
MLA
Yamasaki, H., Mitsuyama, K., Masuda, J., Kuwaki, K., Takedatsu, H., Sugiyama, G., Yamada, S., Sata, M."Roles of high-mobility group box 1 in murine experimental colitis". Molecular Medicine Reports 2.1 (2009): 23-27.
Chicago
Yamasaki, H., Mitsuyama, K., Masuda, J., Kuwaki, K., Takedatsu, H., Sugiyama, G., Yamada, S., Sata, M."Roles of high-mobility group box 1 in murine experimental colitis". Molecular Medicine Reports 2, no. 1 (2009): 23-27. https://doi.org/10.3892/mmr_00000056
Copy and paste a formatted citation
x
Spandidos Publications style
Yamasaki H, Mitsuyama K, Masuda J, Kuwaki K, Takedatsu H, Sugiyama G, Yamada S and Sata M: Roles of high-mobility group box 1 in murine experimental colitis. Mol Med Rep 2: 23-27, 2009.
APA
Yamasaki, H., Mitsuyama, K., Masuda, J., Kuwaki, K., Takedatsu, H., Sugiyama, G. ... Sata, M. (2009). Roles of high-mobility group box 1 in murine experimental colitis. Molecular Medicine Reports, 2, 23-27. https://doi.org/10.3892/mmr_00000056
MLA
Yamasaki, H., Mitsuyama, K., Masuda, J., Kuwaki, K., Takedatsu, H., Sugiyama, G., Yamada, S., Sata, M."Roles of high-mobility group box 1 in murine experimental colitis". Molecular Medicine Reports 2.1 (2009): 23-27.
Chicago
Yamasaki, H., Mitsuyama, K., Masuda, J., Kuwaki, K., Takedatsu, H., Sugiyama, G., Yamada, S., Sata, M."Roles of high-mobility group box 1 in murine experimental colitis". Molecular Medicine Reports 2, no. 1 (2009): 23-27. https://doi.org/10.3892/mmr_00000056
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