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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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January-February 2010 Volume 3 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts

  • Authors:
    • Dawei Guo
    • Qinghong Zhang
    • Jingwen Li
    • Xing Liang
    • Yue Chen
    • Hang Wang
    • Bo Meng

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu 610041, P.R. China
  • Pages: 173-178
    |
    Published online on: January 1, 2010
       https://doi.org/10.3892/mmr_00000236
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Abstract

Fluid shear stress (FSS) is a potent physical cell signal in the regulation of bone remodeling. Although the effects of FSS on bone cells of the osteoblastic lineage have been studied extensively, less is known about the direct effect of FSS on osteoclasts. In this study, we investigated the direct influence of FSS on rat osteoclasts isolated by a classic mechanical anatomical technique. Osteoclasts were exposed to an FSS of 2.9 dynes/cm2 for a given period, or subjected to various magnitudes of FSS for 30 min. Cell morphology under FSS was observed and the expression of the mRNA of ATP6V1A and TCIRG1, two crucial subunits of the vacuolar H+-ATPase gene, was analyzed by quantitative real-time PCR. Changes in osteoclast morphology were apparent after the application of FSS, including increased cell volume, strengthened refraction and decreased transmittance. Time-dependent and dose-dependent increases in ATP6V1A and TCIRG1 mRNA expression were seen in response to FSS within 30 min. However, a duration of FSS exceeding 30 min induced a significant decrease in ATP6V1A and TCIRG1 mRNA expression. FSS therefore appears to be a potent stimulus that is sensed by rat osteoclasts and results in significant changes in cell morphology and the gene regulation of ATP6V1A and TCIRG1. These effects might be strictly dependent on the duration of FSS.

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Copy and paste a formatted citation
Spandidos Publications style
Guo D, Zhang Q, Li J, Liang X, Chen Y, Wang H and Meng B: Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts . Mol Med Rep 3: 173-178, 2010.
APA
Guo, D., Zhang, Q., Li, J., Liang, X., Chen, Y., Wang, H., & Meng, B. (2010). Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts . Molecular Medicine Reports, 3, 173-178. https://doi.org/10.3892/mmr_00000236
MLA
Guo, D., Zhang, Q., Li, J., Liang, X., Chen, Y., Wang, H., Meng, B."Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts ". Molecular Medicine Reports 3.1 (2010): 173-178.
Chicago
Guo, D., Zhang, Q., Li, J., Liang, X., Chen, Y., Wang, H., Meng, B."Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts ". Molecular Medicine Reports 3, no. 1 (2010): 173-178. https://doi.org/10.3892/mmr_00000236
Copy and paste a formatted citation
x
Spandidos Publications style
Guo D, Zhang Q, Li J, Liang X, Chen Y, Wang H and Meng B: Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts . Mol Med Rep 3: 173-178, 2010.
APA
Guo, D., Zhang, Q., Li, J., Liang, X., Chen, Y., Wang, H., & Meng, B. (2010). Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts . Molecular Medicine Reports, 3, 173-178. https://doi.org/10.3892/mmr_00000236
MLA
Guo, D., Zhang, Q., Li, J., Liang, X., Chen, Y., Wang, H., Meng, B."Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts ". Molecular Medicine Reports 3.1 (2010): 173-178.
Chicago
Guo, D., Zhang, Q., Li, J., Liang, X., Chen, Y., Wang, H., Meng, B."Fluid shear stress changes cell morphology and regulates the expression of ATP6V1A and TCIRG1 mRNA in rat osteoclasts ". Molecular Medicine Reports 3, no. 1 (2010): 173-178. https://doi.org/10.3892/mmr_00000236
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