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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Gene expression analysis reveals novel altered genes in nasal polyps

  • Authors:
    • Erica Babeto
    • Marília De Freitas Calmon
    • Paola Jocelan Scarin Provazzi
    • Jucimara Colombo
    • José Antônio Cordeiro
    • Janes Lopes Bonilha
    • Atílio Maximino Fernandes
    • Paula Rahal

  • View Affiliations / Copyright

    Affiliations: Laboratory of Genomics Studies, São Paulo State University - UNESP, São José do Rio Preto, SP, Brazil
  • Pages: 485-490
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000285
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Abstract

Nasal polyposis (NP) is a chronic inflammatory disease of the nasal mucosa characterized by the infiltration of inflammatory cells, mainly eosinophils. Although nasal polyposis occurs in 4% of the population, its physiopathology remains unclear. The aim of this study was to identify and characterize differentially expressed genes that can be used in the prognosis, treatment and elucidation of this physiopathology. To identify novel genes differentially expressed in NP, we applied real-time quantitative PCR to 11 NP samples and to a pool of total RNA from a subset of 13 normal nasal mucosa samples from human autopsies. For selecting genes, the methylated CpG island amplification technique was used. Five differentially methylated clones (ATP2A1, NOVA1, PLCD3, SOLH and TGFβI) were identified. However, these genes presented methylated CpG islands between exons, i.e., not in the promoter regions of the genes. Thus, as shown by real-time PCR, the ATP2A1, SOLH, PLDC3 and TGFβI genes were overexpressed in NP. The genes identified in this study are probably involved in some stage of the process of formation and development of nasal polyposis, as they were highly expressed in the nasal polyp samples.

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Copy and paste a formatted citation
Spandidos Publications style
Babeto E, De Freitas Calmon M, Scarin Provazzi PJ, Colombo J, Cordeiro JA, Bonilha JL, Fernandes AM and Rahal P: Gene expression analysis reveals novel altered genes in nasal polyps. Mol Med Rep 3: 485-490, 2010.
APA
Babeto, E., De Freitas Calmon, M., Scarin Provazzi, P.J., Colombo, J., Cordeiro, J.A., Bonilha, J.L. ... Rahal, P. (2010). Gene expression analysis reveals novel altered genes in nasal polyps. Molecular Medicine Reports, 3, 485-490. https://doi.org/10.3892/mmr_00000285
MLA
Babeto, E., De Freitas Calmon, M., Scarin Provazzi, P. J., Colombo, J., Cordeiro, J. A., Bonilha, J. L., Fernandes, A. M., Rahal, P."Gene expression analysis reveals novel altered genes in nasal polyps". Molecular Medicine Reports 3.3 (2010): 485-490.
Chicago
Babeto, E., De Freitas Calmon, M., Scarin Provazzi, P. J., Colombo, J., Cordeiro, J. A., Bonilha, J. L., Fernandes, A. M., Rahal, P."Gene expression analysis reveals novel altered genes in nasal polyps". Molecular Medicine Reports 3, no. 3 (2010): 485-490. https://doi.org/10.3892/mmr_00000285
Copy and paste a formatted citation
x
Spandidos Publications style
Babeto E, De Freitas Calmon M, Scarin Provazzi PJ, Colombo J, Cordeiro JA, Bonilha JL, Fernandes AM and Rahal P: Gene expression analysis reveals novel altered genes in nasal polyps. Mol Med Rep 3: 485-490, 2010.
APA
Babeto, E., De Freitas Calmon, M., Scarin Provazzi, P.J., Colombo, J., Cordeiro, J.A., Bonilha, J.L. ... Rahal, P. (2010). Gene expression analysis reveals novel altered genes in nasal polyps. Molecular Medicine Reports, 3, 485-490. https://doi.org/10.3892/mmr_00000285
MLA
Babeto, E., De Freitas Calmon, M., Scarin Provazzi, P. J., Colombo, J., Cordeiro, J. A., Bonilha, J. L., Fernandes, A. M., Rahal, P."Gene expression analysis reveals novel altered genes in nasal polyps". Molecular Medicine Reports 3.3 (2010): 485-490.
Chicago
Babeto, E., De Freitas Calmon, M., Scarin Provazzi, P. J., Colombo, J., Cordeiro, J. A., Bonilha, J. L., Fernandes, A. M., Rahal, P."Gene expression analysis reveals novel altered genes in nasal polyps". Molecular Medicine Reports 3, no. 3 (2010): 485-490. https://doi.org/10.3892/mmr_00000285
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