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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells

  • Authors:
    • Jing Liu
    • Xiujuan Qu
    • Ling Xu
    • Ye Zhang
    • Jinglei Qu
    • Kezuo Hou
    • Yunpeng Liu

  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, P.R. China
  • Pages: 491-496
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000286
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Abstract

Human gastric cancer cells are generally believed to be less sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, but the events responsible for this resistance are as yet unclear. In this study, we investigated the role of the phosphoinositide 3-kinase (PI3K)/Akt, nuclear factor κB (NF-κB) and extracellular signal-regulated kinase (ERK) signaling pathways in the TRAIL resistance of gastric cancer cells. TRAIL failed to induce observable apoptosis in the three cell lines. Further investigation revealed that TRAIL engagement led to the activation of PI3K/Akt as well as of NF-κB. The inhibition of PI3K/Akt by a specific inhibitor facilitated TRAIL-induced apoptosis. Blockage of TRAIL-induced NF-κB activation by transient transfection with a phosphorylation-defective mutant IκB also enhanced the sensitivity of cells towards TRAIL. Meanwhile, ERKs were highly activated in the resting cells and were not further activated by TRAIL treatment. However, the inhibition of ERK activity by PD98059 also enhanced the apoptosis-inducing ability of TRAIL. Our data demonstrated that the activation of PI3K/Akt and NF-κB by TRAIL is responsible for resistance to TRAIL in human gastric cancer cells. Blockage of survival signals significantly enhances the apoptosis induced by TRAIL.

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Qu X, Xu L, Zhang Y, Qu J, Hou K and Liu Y: Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. Mol Med Rep 3: 491-496, 2010.
APA
Liu, J., Qu, X., Xu, L., Zhang, Y., Qu, J., Hou, K., & Liu, Y. (2010). Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. Molecular Medicine Reports, 3, 491-496. https://doi.org/10.3892/mmr_00000286
MLA
Liu, J., Qu, X., Xu, L., Zhang, Y., Qu, J., Hou, K., Liu, Y."Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells". Molecular Medicine Reports 3.3 (2010): 491-496.
Chicago
Liu, J., Qu, X., Xu, L., Zhang, Y., Qu, J., Hou, K., Liu, Y."Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells". Molecular Medicine Reports 3, no. 3 (2010): 491-496. https://doi.org/10.3892/mmr_00000286
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Qu X, Xu L, Zhang Y, Qu J, Hou K and Liu Y: Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. Mol Med Rep 3: 491-496, 2010.
APA
Liu, J., Qu, X., Xu, L., Zhang, Y., Qu, J., Hou, K., & Liu, Y. (2010). Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. Molecular Medicine Reports, 3, 491-496. https://doi.org/10.3892/mmr_00000286
MLA
Liu, J., Qu, X., Xu, L., Zhang, Y., Qu, J., Hou, K., Liu, Y."Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells". Molecular Medicine Reports 3.3 (2010): 491-496.
Chicago
Liu, J., Qu, X., Xu, L., Zhang, Y., Qu, J., Hou, K., Liu, Y."Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells". Molecular Medicine Reports 3, no. 3 (2010): 491-496. https://doi.org/10.3892/mmr_00000286
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