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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May-June 2010 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion

  • Authors:
    • Yong Hwan Han
    • Hwa Jin Moon
    • Bo Ra You
    • Yeon Mi Yang
    • Sung Zoo Kim
    • Suhn Hee Kim
    • Woo Hyun Park

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju 561-180, Korea
  • Pages: 519-525
    |
    Published online on: May 1, 2010
       https://doi.org/10.3892/mmr_00000291
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Abstract

Gallic acid (GA) is widely distributed in various plants and foods and has various biological effects. In this study, we investigated the effects of mitogen-activated protein kinase (MEK, JNK or p38) inhibitors on GA-induced Calu-6 lung cancer cell death in relation to reactive oxygen species (ROS) and glutathione (GSH) levels. GA inhibited the growth of Calu-6 cells and induced apoptosis and/or necrosis accompanied by the loss of mitochondrial membrane potential (MMP; Δψm). ROS levels and the number of GSH-depleted cells were observed to be increased at 24 h. MEK inhibitor suppressed cell growth inhibition, death, MMP (Δψm) loss and GSH depletion induced by GA, but failed to suppress the increase in ROS levels. JNK inhibitor also somewhat suppressed cell growth inhibition, MMP (Δψm) loss and GSH depletion induced by GA, and limited the increase in ROS levels. By contrast, p38 inhibitor mildly enhanced GA-induced cell growth inhibition, MMP (Δψm) loss and the increase in ROS levels. In conclusion, MEK inhibitor suppressed GA-induced cell growth inhibition and death in Calu-6 cells. This was related to the prevention of GSH depletion.

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Copy and paste a formatted citation
Spandidos Publications style
Han YH, Moon HJ, You BR, Yang YM, Kim SZ, Kim SH and Park WH: The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion. Mol Med Rep 3: 519-525, 2010.
APA
Han, Y.H., Moon, H.J., You, B.R., Yang, Y.M., Kim, S.Z., Kim, S.H., & Park, W.H. (2010). The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion. Molecular Medicine Reports, 3, 519-525. https://doi.org/10.3892/mmr_00000291
MLA
Han, Y. H., Moon, H. J., You, B. R., Yang, Y. M., Kim, S. Z., Kim, S. H., Park, W. H."The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion". Molecular Medicine Reports 3.3 (2010): 519-525.
Chicago
Han, Y. H., Moon, H. J., You, B. R., Yang, Y. M., Kim, S. Z., Kim, S. H., Park, W. H."The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion". Molecular Medicine Reports 3, no. 3 (2010): 519-525. https://doi.org/10.3892/mmr_00000291
Copy and paste a formatted citation
x
Spandidos Publications style
Han YH, Moon HJ, You BR, Yang YM, Kim SZ, Kim SH and Park WH: The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion. Mol Med Rep 3: 519-525, 2010.
APA
Han, Y.H., Moon, H.J., You, B.R., Yang, Y.M., Kim, S.Z., Kim, S.H., & Park, W.H. (2010). The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion. Molecular Medicine Reports, 3, 519-525. https://doi.org/10.3892/mmr_00000291
MLA
Han, Y. H., Moon, H. J., You, B. R., Yang, Y. M., Kim, S. Z., Kim, S. H., Park, W. H."The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion". Molecular Medicine Reports 3.3 (2010): 519-525.
Chicago
Han, Y. H., Moon, H. J., You, B. R., Yang, Y. M., Kim, S. Z., Kim, S. H., Park, W. H."The MEK inhibitor PD98059 attenuates growth inhibition and death in gallic acid-treated Calu-6 lung cancer cells by preventing glutathione depletion". Molecular Medicine Reports 3, no. 3 (2010): 519-525. https://doi.org/10.3892/mmr_00000291
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