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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2010 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2010 Volume 3 Issue 4

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Article

Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA

  • Authors:
    • Yizhou Jiang
    • Yi Wang
    • Zijie Su
    • Ling Yang
    • Weiwei Guo
    • Wen Liu
    • Ji Zuo

  • View Affiliations / Copyright

    Affiliations: Department of Cellular and Genetic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China
  • Pages: 613-619
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/mmr_00000305
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Abstract

Proteasome inhibitors and histone deacetylase (HDAC) inhibitors are two promising groups of anti-cancer agents. In this study, we examined the apoptotic effects of the proteasome inhibitor bortezomib and HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) in human cervical carcinoma HeLa cells. Compared to treatment with bortezomib or SAHA alone, co-exposure with these two agents synergistically resulted in the massive apoptosis of HeLa cells, consistent with a significant increase in caspase-3 activation. We then investigated the mechanisms underlying this effect. The combination of bortezomib and SAHA caused an increase in the ratio of bax/bcl-2 expression, inhibited the nuclear transportation of NF-κB, and down-regulated Akt expression and phosphorylation in HeLa cells. In conclusion, bortezomib and SAHA cooperatively stimulate apoptosis in HeLa cells through the inhibition of several cyto-protective signalling pathways. This is the first report of synergistic apoptotic effect achieved with a proteasome inhibitor and HDAC inhibitor in HeLa cells. Thus, the results build the framework for clinical trials using combined proteasome and HDAC inhibition in the treatment of human cervical carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Wang Y, Su Z, Yang L, Guo W, Liu W and Zuo J: Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA . Mol Med Rep 3: 613-619, 2010.
APA
Jiang, Y., Wang, Y., Su, Z., Yang, L., Guo, W., Liu, W., & Zuo, J. (2010). Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA . Molecular Medicine Reports, 3, 613-619. https://doi.org/10.3892/mmr_00000305
MLA
Jiang, Y., Wang, Y., Su, Z., Yang, L., Guo, W., Liu, W., Zuo, J."Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA ". Molecular Medicine Reports 3.4 (2010): 613-619.
Chicago
Jiang, Y., Wang, Y., Su, Z., Yang, L., Guo, W., Liu, W., Zuo, J."Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA ". Molecular Medicine Reports 3, no. 4 (2010): 613-619. https://doi.org/10.3892/mmr_00000305
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Wang Y, Su Z, Yang L, Guo W, Liu W and Zuo J: Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA . Mol Med Rep 3: 613-619, 2010.
APA
Jiang, Y., Wang, Y., Su, Z., Yang, L., Guo, W., Liu, W., & Zuo, J. (2010). Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA . Molecular Medicine Reports, 3, 613-619. https://doi.org/10.3892/mmr_00000305
MLA
Jiang, Y., Wang, Y., Su, Z., Yang, L., Guo, W., Liu, W., Zuo, J."Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA ". Molecular Medicine Reports 3.4 (2010): 613-619.
Chicago
Jiang, Y., Wang, Y., Su, Z., Yang, L., Guo, W., Liu, W., Zuo, J."Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA ". Molecular Medicine Reports 3, no. 4 (2010): 613-619. https://doi.org/10.3892/mmr_00000305
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