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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2010 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury

  • Authors:
    • Xia Xie
    • Hai-Tao Wang
    • Chun-Li Li
    • Xu-Hong Gao
    • Jin-Lan Ding
    • Hai-Hua Zhao
    • Yong-Li Lu

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Basic Medical Sciences College, China Medical University, Liaoning 110001, P.R. China
  • Pages: 635-639
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/mmr_00000308
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Abstract

Excessive accumulation of β-amyloid (Aβ) has been proposed as a pivotal event in the pathogenesis of Alzheimer's disease. Possible mechanisms underlying Aβ-induced neuronal cytotoxicity include oxidative stress and apoptosis. Reactive oxygen species (ROS) have been proposed to be involved in the apoptotic mechanism of Aβ-induced cytotoxicity. Ginsenoside Rb1 (GRb1), which is among the key compounds of ginsenoside, found in ginseng, may be a potent scavenger of ROS. To examine the potential protective effect of GRb1 in Aβ25-35-induced cytotoxicity, cells were pre-treated with GRb1 for 24 h, and then Aβ25-35 was added to the medium for an additional 24 h. Exposure to Aβ led to the accumulation of ROS and lipid peroxidation, eventually causing a decrease in the Bcl-2/Bax ratio, caspase-3 activation, cell apoptosis and cell death. Pre-treatment with GRb1 not only inhibited Aβ-induced ROS overproduction and lipid peroxidation, but also increased the Bcl-2/Bax ratio and attenuated caspase-3 activation, thereby improving cell survival. GRb1 may therefore act as a ROS scavenger, and such antioxidant properties may play a protective role against Aβ-induced cell injury. Further exploration of GRb1 antioxidant properties may provide novel therapeutic strategies for the treatment of Alzheimer's disease.

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Copy and paste a formatted citation
Spandidos Publications style
Xie X, Wang H, Li C, Gao X, Ding J, Zhao H and Lu Y: Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury . Mol Med Rep 3: 635-639, 2010.
APA
Xie, X., Wang, H., Li, C., Gao, X., Ding, J., Zhao, H., & Lu, Y. (2010). Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury . Molecular Medicine Reports, 3, 635-639. https://doi.org/10.3892/mmr_00000308
MLA
Xie, X., Wang, H., Li, C., Gao, X., Ding, J., Zhao, H., Lu, Y."Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury ". Molecular Medicine Reports 3.4 (2010): 635-639.
Chicago
Xie, X., Wang, H., Li, C., Gao, X., Ding, J., Zhao, H., Lu, Y."Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury ". Molecular Medicine Reports 3, no. 4 (2010): 635-639. https://doi.org/10.3892/mmr_00000308
Copy and paste a formatted citation
x
Spandidos Publications style
Xie X, Wang H, Li C, Gao X, Ding J, Zhao H and Lu Y: Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury . Mol Med Rep 3: 635-639, 2010.
APA
Xie, X., Wang, H., Li, C., Gao, X., Ding, J., Zhao, H., & Lu, Y. (2010). Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury . Molecular Medicine Reports, 3, 635-639. https://doi.org/10.3892/mmr_00000308
MLA
Xie, X., Wang, H., Li, C., Gao, X., Ding, J., Zhao, H., Lu, Y."Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury ". Molecular Medicine Reports 3.4 (2010): 635-639.
Chicago
Xie, X., Wang, H., Li, C., Gao, X., Ding, J., Zhao, H., Lu, Y."Ginsenoside Rb1 protects PC12 cells against β-amyloid-induced cell injury ". Molecular Medicine Reports 3, no. 4 (2010): 635-639. https://doi.org/10.3892/mmr_00000308
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