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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2010 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment

  • Authors:
    • Kana Kuwamoto
    • Yuri Takeda
    • Akiko Shirai
    • Tsutomu Nakagawa
    • Shunsaku Takeishi
    • Shinji Ihara
    • Yasuhide Miyamoto
    • Shinichiro Shinzaki
    • Jeong Heon Ko
    • Eiji Miyoshi
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
  • Pages: 651-656
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/mmr_00000311
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Abstract

α2-Heremans-Schmid glycoprotein (human fetuin) is one of numerous serum proteins produced in the liver. Recently, the biological functions of fetuin, such as calcification and insulin resistance, have been clarified. However, these effects appear to be indirect, occurring through binding to other molecules. When equal amounts of fetuin in sera were treated with chymotrypsin, resistance to the protease treatment was observed in patients with pancreatic cancer, but not in normal volunteers. To investigate the molecular mechanism behind this resistance, gel-filtration chromatography was performed. The results revealed that high molecular types of fetuin showed a resistance to protease treatment. When fetuin was purified from sera of patients with pancreatic cancer and normal volunteers, certain types of proteins, including haptoglobin (which binds to fetuin derived from pancreatic cancer patients), were identified using mass spectrometry. Furthermore, the oligosaccharide structures of fetuin analyzed with lectin microarray differed between pancreatic cancer patients and normal volunteers. This macro/micro heterogeneity of fetuin might contribute to pancreatic cancer resistance to chymotrypsin treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Kuwamoto K, Takeda Y, Shirai A, Nakagawa T, Takeishi S, Ihara S, Miyamoto Y, Shinzaki S, Ko JH, Miyoshi E, Miyoshi E, et al: Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment . Mol Med Rep 3: 651-656, 2010.
APA
Kuwamoto, K., Takeda, Y., Shirai, A., Nakagawa, T., Takeishi, S., Ihara, S. ... Miyoshi, E. (2010). Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment . Molecular Medicine Reports, 3, 651-656. https://doi.org/10.3892/mmr_00000311
MLA
Kuwamoto, K., Takeda, Y., Shirai, A., Nakagawa, T., Takeishi, S., Ihara, S., Miyamoto, Y., Shinzaki, S., Ko, J. H., Miyoshi, E."Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment ". Molecular Medicine Reports 3.4 (2010): 651-656.
Chicago
Kuwamoto, K., Takeda, Y., Shirai, A., Nakagawa, T., Takeishi, S., Ihara, S., Miyamoto, Y., Shinzaki, S., Ko, J. H., Miyoshi, E."Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment ". Molecular Medicine Reports 3, no. 4 (2010): 651-656. https://doi.org/10.3892/mmr_00000311
Copy and paste a formatted citation
x
Spandidos Publications style
Kuwamoto K, Takeda Y, Shirai A, Nakagawa T, Takeishi S, Ihara S, Miyamoto Y, Shinzaki S, Ko JH, Miyoshi E, Miyoshi E, et al: Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment . Mol Med Rep 3: 651-656, 2010.
APA
Kuwamoto, K., Takeda, Y., Shirai, A., Nakagawa, T., Takeishi, S., Ihara, S. ... Miyoshi, E. (2010). Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment . Molecular Medicine Reports, 3, 651-656. https://doi.org/10.3892/mmr_00000311
MLA
Kuwamoto, K., Takeda, Y., Shirai, A., Nakagawa, T., Takeishi, S., Ihara, S., Miyamoto, Y., Shinzaki, S., Ko, J. H., Miyoshi, E."Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment ". Molecular Medicine Reports 3.4 (2010): 651-656.
Chicago
Kuwamoto, K., Takeda, Y., Shirai, A., Nakagawa, T., Takeishi, S., Ihara, S., Miyamoto, Y., Shinzaki, S., Ko, J. H., Miyoshi, E."Identification of various types of α2-HS glycoprotein in sera of patients with pancreatic cancer: Possible implication in resistance to protease treatment ". Molecular Medicine Reports 3, no. 4 (2010): 651-656. https://doi.org/10.3892/mmr_00000311
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