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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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July-August 2010 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells

  • Authors:
    • Shi-Ping Chen
    • Mei Dong
    • Kazuko Kita
    • Qin-Wen Shi
    • Bing Cong
    • Wen-Zhi Guo
    • Shigeru Sugaya
    • Katsuo Sugita
    • Nobuo Suzuki

  • View Affiliations / Copyright

    Affiliations: Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
  • Pages: 673-678
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/mmr_00000315
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Abstract

Two abietane and one labdane type diterpenoids were isolated from the methanol extracts of Torreya nucifera pulp and investigated for their ability to inhibit the growth of human cancer cells. Among the three compounds, the labdane compound kayadiol was found to have the most effective inhibitory effect against a wide variety of human cancer cells. Using the MTT assay, kayadiol was determined to have an IC50 (50% inhibition concentration) of 30 µM in HeLa cells, and also to exhibit anti-proliferative effects towards six other human cancer cell lines, with IC50 values of 30-50 µM. Kayadiol treatment of HeLa cells resulted in a dose-dependent generation of apoptotic events, including DNA laddering (≤100 µM). Moreover, kayadiol-treated HeLa cells showed activation of caspases-3 and -9, as well as an increase in the depolarization of mitochondrial membrane potential and the Bax/Bcl-2 ratio. These results indicate that a mitochondria-related apoptotic pathway is involved in the kayadiol-induced death of HeLa cells. Kayadiol is therefore a promising novel anti-proliferative agent and merits further investigation.

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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Dong M, Kita K, Shi Q, Cong B, Guo W, Sugaya S, Sugita K and Suzuki N: Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells . Mol Med Rep 3: 673-678, 2010.
APA
Chen, S., Dong, M., Kita, K., Shi, Q., Cong, B., Guo, W. ... Suzuki, N. (2010). Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells . Molecular Medicine Reports, 3, 673-678. https://doi.org/10.3892/mmr_00000315
MLA
Chen, S., Dong, M., Kita, K., Shi, Q., Cong, B., Guo, W., Sugaya, S., Sugita, K., Suzuki, N."Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells ". Molecular Medicine Reports 3.4 (2010): 673-678.
Chicago
Chen, S., Dong, M., Kita, K., Shi, Q., Cong, B., Guo, W., Sugaya, S., Sugita, K., Suzuki, N."Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells ". Molecular Medicine Reports 3, no. 4 (2010): 673-678. https://doi.org/10.3892/mmr_00000315
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Dong M, Kita K, Shi Q, Cong B, Guo W, Sugaya S, Sugita K and Suzuki N: Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells . Mol Med Rep 3: 673-678, 2010.
APA
Chen, S., Dong, M., Kita, K., Shi, Q., Cong, B., Guo, W. ... Suzuki, N. (2010). Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells . Molecular Medicine Reports, 3, 673-678. https://doi.org/10.3892/mmr_00000315
MLA
Chen, S., Dong, M., Kita, K., Shi, Q., Cong, B., Guo, W., Sugaya, S., Sugita, K., Suzuki, N."Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells ". Molecular Medicine Reports 3.4 (2010): 673-678.
Chicago
Chen, S., Dong, M., Kita, K., Shi, Q., Cong, B., Guo, W., Sugaya, S., Sugita, K., Suzuki, N."Anti-proliferative and apoptosis-inducible activity of labdane and abietane diterpenoids from the pulp of Torreya nucifera in HeLa cells ". Molecular Medicine Reports 3, no. 4 (2010): 673-678. https://doi.org/10.3892/mmr_00000315
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