Redox state of albumin is not associated with colloid osmotic pressure

Sakata,Masahiro; Kawaguchi,Takumi; Taniguchi,Eitaro; Nakayama,Akira; Ishizaki,Sonoko; Sonaka,Ichiro; Maganuma,Miyako; Nakamura,Toru; Itou,Minoru; Oriishi,Tetsuharu; Abe,Mitsuhiko; Yanagimoto,Chikatoshi; Koga,Hironori; Harada,Masaru; Sakamoto,Teruo; Oda,Shigeto; Sata,Michio

doi:10.3892/mmr_00000317

July-August 2010 Volume 3 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

July-August 2010 Volume 3 Issue 4

Full Size Image

Article

Redox state of albumin is not associated with colloid osmotic pressure

Authors:
- Masahiro Sakata
- Takumi Kawaguchi
- Eitaro Taniguchi
- Akira Nakayama
- Sonoko Ishizaki
- Ichiro Sonaka
- Miyako Maganuma
- Toru Nakamura
- Minoru Itou
- Tetsuharu Oriishi
- Mitsuhiko Abe
- Chikatoshi Yanagimoto
- Hironori Koga
- Masaru Harada
- Teruo Sakamoto
- Shigeto Oda
- Michio Sata
View Affiliations / Copyright

Affiliations: Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan. sakata_masahiro@med.kurume-u.ac.jp
Pages: 685-687
|
Published online on: July 1, 2010

https://doi.org/10.3892/mmr_00000317
Expand metrics +

Abstract

Serum albumin exists in oxidized and reduced forms. Although the oxidation of albumin affects some of its functions, the relationship between oxidized albumin and colloid osmotic pressure (COP) remains unclear. The aim of this study was to determine whether there is an association between oxidized albumin and COP. Blood samples from 20 healthy volunteers were divided into two aliquots in order to prepare reduced (n=20) and oxidized albumin samples (n=20). This was achieved by treatment with L-cysteine and a redox-stabilizing agent before and after incubation at 37°C for 24 h. The percentage of oxidized albumin was determined by high-performance liquid chromatography. COP was measured using a colloid osmometer. Reduced and oxidized albumin samples showed 100% of reduced and 100% of oxidized albumin, respectively. There were no significant differences in albumin level and total protein level between the reduced and the oxidized albumin samples. No significant change was seen in COP between the reduced and the oxidized albumin samples (reduced albumin, 17.4±0.2 mmHg; oxidized albumin, 17.3±0.2 mmHg; P=0.465). Therefore, there is no significant difference in COP between reduced and oxidized albumin samples.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Redox state of albumin is not associated with colloid osmotic pressure

This article is mentioned in:

Abstract

Related Articles