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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2011 Volume 2 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September-October 2011 Volume 2 Issue 5

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Article

Role of ERCC5 polymorphism in risk of hepatocellular carcinoma

  • Authors:
    • Angela J. Yoon
    • Wu‑Hsien Kuo
    • Chiao‑Wen Lin
    • Shun‑Fa Yang
  • View Affiliations / Copyright

    Affiliations: College of Dental Medicine, Columbia University, New York City, NY, USA, Department of Medicine, Armed‑Force Taichung General Hospital, Taichung, Taiwan, R.O.C., Institute of Biochemistry and Biotechnology, Taichung, Taiwan, R.O.C., Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, R.O.C.
  • Pages: 911-914
    |
    Published online on: June 10, 2011
       https://doi.org/10.3892/ol.2011.325
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Abstract

Excision repair cross‑complementing rodent repair deficiency, complementation group 5 (ERCC5, XPG) is a key molecule in DNA damage repair. We analyzed the contribution of ERCC5 rs751402 polymorphism in increased susceptibility to hepatocellular carcinoma (HCC). A total of 96 patients diagnosed with HCC and 336 healthy controls provided blood samples for analysis of rs751402 genotypes. Demographic data and information on habitual use of tobacco and alcohol were collected. After adjusting for covariates, rs751402 homozygocity for allele C was found to confer a statistically significant protection [adjusted odds ratio (AOR)=0.56; 95% CI, 0.35‑0.89; p=0.01] against HCC, whereas rs751402 T alleles were associated with increased risk (AOR=1.69; 95% CI, 0.74‑3.87). Individuals with the inherited ERCC rs751402 CC genotype may experience significant protection against HCC, whereas individuals with T alleles appear to be exposed to higher risk.

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Copy and paste a formatted citation
Spandidos Publications style
Yoon AJ, Kuo WH, Lin CW and Yang SF: Role of ERCC5 polymorphism in risk of hepatocellular carcinoma. Oncol Lett 2: 911-914, 2011.
APA
Yoon, A.J., Kuo, W., Lin, C., & Yang, S. (2011). Role of ERCC5 polymorphism in risk of hepatocellular carcinoma. Oncology Letters, 2, 911-914. https://doi.org/10.3892/ol.2011.325
MLA
Yoon, A. J., Kuo, W., Lin, C., Yang, S."Role of ERCC5 polymorphism in risk of hepatocellular carcinoma". Oncology Letters 2.5 (2011): 911-914.
Chicago
Yoon, A. J., Kuo, W., Lin, C., Yang, S."Role of ERCC5 polymorphism in risk of hepatocellular carcinoma". Oncology Letters 2, no. 5 (2011): 911-914. https://doi.org/10.3892/ol.2011.325
Copy and paste a formatted citation
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Spandidos Publications style
Yoon AJ, Kuo WH, Lin CW and Yang SF: Role of ERCC5 polymorphism in risk of hepatocellular carcinoma. Oncol Lett 2: 911-914, 2011.
APA
Yoon, A.J., Kuo, W., Lin, C., & Yang, S. (2011). Role of ERCC5 polymorphism in risk of hepatocellular carcinoma. Oncology Letters, 2, 911-914. https://doi.org/10.3892/ol.2011.325
MLA
Yoon, A. J., Kuo, W., Lin, C., Yang, S."Role of ERCC5 polymorphism in risk of hepatocellular carcinoma". Oncology Letters 2.5 (2011): 911-914.
Chicago
Yoon, A. J., Kuo, W., Lin, C., Yang, S."Role of ERCC5 polymorphism in risk of hepatocellular carcinoma". Oncology Letters 2, no. 5 (2011): 911-914. https://doi.org/10.3892/ol.2011.325
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