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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2011 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway

  • Authors:
    • Xiaoxia Liu
    • Xiaobo Li
    • Lianhua Yin
    • Jingxin Ding
    • Hongyan Jin
    • Youji Feng

  • View Affiliations / Copyright

    Affiliations: The Obstetrics and Gynecology Hospital, Fudan University, Yangpu, Shanghai 200090, P.R. China, Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai 200032, P.R. China
  • Pages: 891-897
    |
    Published online on: July 5, 2011
       https://doi.org/10.3892/ol.2011.338
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Abstract

Genistein, the most abundant phytoestrogen in soybeans, may bind to estrogen receptors and perform anticancer activities. Choriocarcinoma is a malignant, trophoblastic and aggressive cancer of the placenta. Few studies are currently available concerning the effects of genistein on choriocarcinoma. In the present study, we investigated the effect of genistein on the invasive potential of the choriocarcinoma cell line JAR and its underlying mechanism. Our data revealed that genistein inhibited JAR cell invasion in a dose-dependent manner by a matrigel invasion assay. Moreover, genistein was found to have decreased the metastasis-associated gene MTA3 mRNA level, increased the transcriptional suppressor Snail mRNA level and upregulated the protein expression of the cell-cell adhesion molecule E-cadherin by real-time RT-PCR and Western blot analysis, respectively. ERβ siRNA was used to knock down ERβ expression in JAR cells. In the ERβ-knockdown JAR cells, genistein failed to inhibit JAR cell invasion. The effects of genistein on MTA3, Snail and E-cadherin expression were also eradicated following ERβ siRNA transfection. These results demonstrated that genistein triggered the MTA3/Snail/E-cadherin regulatory pathway by binding with ERβ, thereby inhibiting JAR cell invasion. In conclusion, our findings have significant implications for the prevention and therapy of choriocarcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Li X, Yin L, Ding J, Jin H and Feng Y: Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway. Oncol Lett 2: 891-897, 2011.
APA
Liu, X., Li, X., Yin, L., Ding, J., Jin, H., & Feng, Y. (2011). Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway. Oncology Letters, 2, 891-897. https://doi.org/10.3892/ol.2011.338
MLA
Liu, X., Li, X., Yin, L., Ding, J., Jin, H., Feng, Y."Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway". Oncology Letters 2.5 (2011): 891-897.
Chicago
Liu, X., Li, X., Yin, L., Ding, J., Jin, H., Feng, Y."Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway". Oncology Letters 2, no. 5 (2011): 891-897. https://doi.org/10.3892/ol.2011.338
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Li X, Yin L, Ding J, Jin H and Feng Y: Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway. Oncol Lett 2: 891-897, 2011.
APA
Liu, X., Li, X., Yin, L., Ding, J., Jin, H., & Feng, Y. (2011). Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway. Oncology Letters, 2, 891-897. https://doi.org/10.3892/ol.2011.338
MLA
Liu, X., Li, X., Yin, L., Ding, J., Jin, H., Feng, Y."Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway". Oncology Letters 2.5 (2011): 891-897.
Chicago
Liu, X., Li, X., Yin, L., Ding, J., Jin, H., Feng, Y."Genistein inhibits placental choriocarcinoma cell line JAR invasion through ERβ/MTA3/Snail/E-cadherin pathway". Oncology Letters 2, no. 5 (2011): 891-897. https://doi.org/10.3892/ol.2011.338
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