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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-October 2011 Volume 2 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer

  • Authors:
    • Yukiko Kishida
    • Takashi Hirose
    • Takao Shirai
    • Tomohide Sugiyama
    • Soujiro Kusumoto
    • Toshimitsu Yamaoka
    • Kentaro Okuda
    • Mitsuru Adachi
    • Akihiro Nakamura

  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutics, Showa University School of Medicine, Shinagawa, Tokyo 142-8666, Japan, Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Showa University School of Medicine, Tokyo 142-8666, Japan
  • Pages: 949-955
    |
    Published online on: July 5, 2011
       https://doi.org/10.3892/ol.2011.348
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Abstract

The aim of the present study was to assess whether myelosuppression during concurrent chemoradiotherapy is a prognostic factor for patients with locally advanced non‑small cell lung cancer (NSCLC). We retrospectively analyzed 86 patients with NSCLC who received concurrent platinum-based chemoradiotherapy. Patients were classified into two groups (grades 0-2 and 3-4) according to the most severe neutropenia, anemia or thrombocytopenia observed during concurrent chemoradiotherapy, and survival time and progression-free survival (PFS) time were analyzed. Univariate analysis revealed that overall survival time was significantly longer in patients with grade 0-2 anemia than in those with grade 3-4 anemia (p=0.02). Survival time did not differ significantly on the basis of the severity of neutropenia or thrombocytopenia. Although pre-treatment white blood cell count was a further prognostic factor in univariate analysis, multivariate analysis revealed that the only independent prognostic factor for overall survival time was anemia. Disease stage was an independent prognostic factor for PFS (p=0.04), whereas neutropenia, anemia and thrombocytopenia were not. In conclusion, the severity of anemia during concurrent chemoradiotherapy may be a useful prognostic factor in patients with locally advanced NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Kishida Y, Hirose T, Shirai T, Sugiyama T, Kusumoto S, Yamaoka T, Okuda K, Adachi M and Nakamura A: Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer. Oncol Lett 2: 949-955, 2011.
APA
Kishida, Y., Hirose, T., Shirai, T., Sugiyama, T., Kusumoto, S., Yamaoka, T. ... Nakamura, A. (2011). Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer. Oncology Letters, 2, 949-955. https://doi.org/10.3892/ol.2011.348
MLA
Kishida, Y., Hirose, T., Shirai, T., Sugiyama, T., Kusumoto, S., Yamaoka, T., Okuda, K., Adachi, M., Nakamura, A."Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer". Oncology Letters 2.5 (2011): 949-955.
Chicago
Kishida, Y., Hirose, T., Shirai, T., Sugiyama, T., Kusumoto, S., Yamaoka, T., Okuda, K., Adachi, M., Nakamura, A."Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer". Oncology Letters 2, no. 5 (2011): 949-955. https://doi.org/10.3892/ol.2011.348
Copy and paste a formatted citation
x
Spandidos Publications style
Kishida Y, Hirose T, Shirai T, Sugiyama T, Kusumoto S, Yamaoka T, Okuda K, Adachi M and Nakamura A: Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer. Oncol Lett 2: 949-955, 2011.
APA
Kishida, Y., Hirose, T., Shirai, T., Sugiyama, T., Kusumoto, S., Yamaoka, T. ... Nakamura, A. (2011). Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer. Oncology Letters, 2, 949-955. https://doi.org/10.3892/ol.2011.348
MLA
Kishida, Y., Hirose, T., Shirai, T., Sugiyama, T., Kusumoto, S., Yamaoka, T., Okuda, K., Adachi, M., Nakamura, A."Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer". Oncology Letters 2.5 (2011): 949-955.
Chicago
Kishida, Y., Hirose, T., Shirai, T., Sugiyama, T., Kusumoto, S., Yamaoka, T., Okuda, K., Adachi, M., Nakamura, A."Myelosuppression induced by concurrent chemoradiotherapy as a prognostic factor for patients with locally advanced non-small cell lung cancer". Oncology Letters 2, no. 5 (2011): 949-955. https://doi.org/10.3892/ol.2011.348
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