Clinical characteristics of hepatocellular carcinoma in elderly patients

Honda,Takuya; Miyaaki,Hisamitsu; Ichikawa,Tatsuki; Taura,Naota; Miuma,Satoshi; Shibata,Hidetaka; Isomoto,Hajime; Takeshima,Fuminao; Nakao,Kazuhiko

doi:10.3892/ol.2011.359

September-October 2011 Volume 2 Issue 5

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September-October 2011 Volume 2 Issue 5

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Article

Clinical characteristics of hepatocellular carcinoma in elderly patients

Authors:
- Takuya Honda
- Hisamitsu Miyaaki
- Tatsuki Ichikawa
- Naota Taura
- Satoshi Miuma
- Hidetaka Shibata
- Hajime Isomoto
- Fuminao Takeshima
- Kazuhiko Nakao
View Affiliations / Copyright

Affiliations: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan
Pages: 851-854
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Published online on: July 5, 2011

https://doi.org/10.3892/ol.2011.359
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Abstract

The incidence of hepatocellular carcinoma (HCC) in elderly patients in Japan has been on the increase. The aim of the present study was to evaluate the impact of aging on the clinicopathological findings and the survival of HCC patients. A total of 624 patients with HCC were examined in this study. The patients were classified according to their age at the time of diagnosis: one group comprised younger patients (<75 years; n=544) and the second comprised elderly patients [(≥75 years; n=80, (12%)]. Results showed that there were significantly more female patients (younger:elderly, 22:36; p=0.005), normal livers (younger:elderly, 0.3:6%; p=0.0002), non-viral HCC (younger:elderly, 11:31%; p<0.001) and solitary tumors (younger:elderly, 53:76%; p=0.0008) in the elderly group. Five out of seven (71%) non-B non-C (NBNC) HCC patients who developed HCC in the normal liver were elderly patients. Survival between the younger and elderly HCC groups was not significantly different (younger:elderly, 4.38:3.45 years; p=0.665). Additionally, elderly HCC patients had fewer tumors, more mild underlying liver damage, and more frequent NBNC HCC. Their prognosis was not necessarily poorer than that of the younger HCC patients. Additionally, it appears that elderly patients develop HCC even without fibrosis. Therefore, aging may be a factor affecting hepatocarcinogenesis.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical characteristics of hepatocellular carcinoma in elderly patients

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Abstract

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