Immunohistochemical study of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer

  • Authors:
    • Li Xia
    • Xiu-Zhen Xue
  • View Affiliations

  • Published online on: January 12, 2012     https://doi.org/10.3892/ol.2012.564
  • Pages: 839-844
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Abstract

The present study aimed to evaluate the expression of NF-κB p65, c-IAP2 and caspase-3 in human cervical cancer. Immunohistochemistry was performed to determine the levels of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer. Our study found overexpression of NF-κB p65 and c-IAP2 and reduced expression of caspase-3 in cervical cancer and cervical intraepithelial neoplasia (CIN) II-III. The expression of these molecules had no significant differences in the various clinical stages of cervical cancer, but the expression levels of NF-κB p65 and c-IAP2 in poorly differentiated tumors and metastatic lymph nodes were higher than levels in well-differentiated tumors and non-metastatic lymph nodes. By contrast, caspase-3 expression in well-differentiated tumors and non-metastatic lymph nodes was higher than that in poorly differentiated tumors and metastatic lymph nodes. Overexpression of NF-κB p65 and c-IAP2 and reduced expression of caspase-3 in cervical cancer may be important in the tumorigenesis and development of cervical cancer, and they may be useful as biomarkers to estimate progression of cervical cancer.

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April 2012
Volume 3 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xia L and Xia L: Immunohistochemical study of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer. Oncol Lett 3: 839-844, 2012
APA
Xia, L., & Xia, L. (2012). Immunohistochemical study of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer. Oncology Letters, 3, 839-844. https://doi.org/10.3892/ol.2012.564
MLA
Xia, L., Xue, X."Immunohistochemical study of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer". Oncology Letters 3.4 (2012): 839-844.
Chicago
Xia, L., Xue, X."Immunohistochemical study of NF-κB p65, c-IAP2 and caspase-3 expression in cervical cancer". Oncology Letters 3, no. 4 (2012): 839-844. https://doi.org/10.3892/ol.2012.564