Proteomic studies in breast cancer (Review)

  • Authors:
    • Xian-Ju Qin
    • Bruce X. Ling
  • View Affiliations

  • Published online on: January 18, 2012     https://doi.org/10.3892/ol.2012.573
  • Pages: 735-743
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Abstract

Breast cancer is one of the most common types of invasive cancer in females worldwide. Despite major advances in early cancer detection and emerging therapeutic strategies, further improvement has to be achieved for precise diagnosis to reduce the chance of metastasis and relapses. Recent proteomic technologies have offered a promising opportunity for the identification of new breast cancer biomarkers. Matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry (MALDI-TOF MS) and the derived surface-enhanced laser desorption/ionization mass spectrometry (SELDI-TOF MS) enable the development of high-throughput proteome analysis based on comprehensive reliable biomarkers. In this review, we examined proteomic technologies and their applications, and provided focus on the proteomics-based profiling analyses of tumor tissues/cells in order to identify and confirm novel biomarkers of breast cancer.

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April 2012
Volume 3 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
APA
Qin, X., & Qin, X. (2012). Proteomic studies in breast cancer (Review). Oncology Letters, 3, 735-743. https://doi.org/10.3892/ol.2012.573
MLA
Qin, X., Ling, B. X."Proteomic studies in breast cancer (Review)". Oncology Letters 3.4 (2012): 735-743.
Chicago
Qin, X., Ling, B. X."Proteomic studies in breast cancer (Review)". Oncology Letters 3, no. 4 (2012): 735-743. https://doi.org/10.3892/ol.2012.573