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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April 2012 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy

  • Authors:
    • Shi Chen
    • Xingyu Feng
    • Yuanfang Li
    • Xiuhong Yuan
    • Zhiwei Zhou
    • Yingbo Chen

  • View Affiliations / Copyright

    Affiliations: Department of Gastropancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, P.R. China
  • Pages: 781-786
    |
    Published online on: January 19, 2012
       https://doi.org/10.3892/ol.2012.577
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Abstract

The purpose of this study was to compare the efficacy and safety of capecitabine and oxaliplatin (XELOX) with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX6) for advanced gastric cancer following total gastrectomy. We performed a retrospective study of 148 gastric cancer patients undergoing total gastrectomy combined with adjuvant chemotherapy from January, 2003 to June, 2009. The follow-up lasted until December, 2010. The Chi-square test and Kaplan-Meier methods were employed to compare the adverse events and prognosis. The total 1-, 3- and 5-year survival rates were 95, 80 and 32%, respectively, and there was no significant difference between the two groups (P=0.273). Similarly, the total incidence of side effects was similar, but each treatment was associated with unique disturbances. The number of patients developing hand‑foot syndrome in the XELOX group was far higher compared to the FOLFOX6 group (P=0.000). By contrast, more patients in the FOLFOX6 group suffered from nausea (P=0.024), vomiting (P=0.029), alopecia (P=0.033) and peripheral phlebitis (P=0.004). The total completion rate of the XELOX group was higher compared to the FOLFOX6 group (P=0.015). No significant difference was found in the prognosis of patients receiving XELOX therapy or FOLFOX6 therapy following total gastrectomy. XELOX was, however, more tolerable for patients with total gastrectomy.

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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Feng X, Li Y, Yuan X, Zhou Z and Chen Y: Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy. Oncol Lett 3: 781-786, 2012.
APA
Chen, S., Feng, X., Li, Y., Yuan, X., Zhou, Z., & Chen, Y. (2012). Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy. Oncology Letters, 3, 781-786. https://doi.org/10.3892/ol.2012.577
MLA
Chen, S., Feng, X., Li, Y., Yuan, X., Zhou, Z., Chen, Y."Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy". Oncology Letters 3.4 (2012): 781-786.
Chicago
Chen, S., Feng, X., Li, Y., Yuan, X., Zhou, Z., Chen, Y."Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy". Oncology Letters 3, no. 4 (2012): 781-786. https://doi.org/10.3892/ol.2012.577
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Feng X, Li Y, Yuan X, Zhou Z and Chen Y: Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy. Oncol Lett 3: 781-786, 2012.
APA
Chen, S., Feng, X., Li, Y., Yuan, X., Zhou, Z., & Chen, Y. (2012). Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy. Oncology Letters, 3, 781-786. https://doi.org/10.3892/ol.2012.577
MLA
Chen, S., Feng, X., Li, Y., Yuan, X., Zhou, Z., Chen, Y."Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy". Oncology Letters 3.4 (2012): 781-786.
Chicago
Chen, S., Feng, X., Li, Y., Yuan, X., Zhou, Z., Chen, Y."Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy". Oncology Letters 3, no. 4 (2012): 781-786. https://doi.org/10.3892/ol.2012.577
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