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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April 2012 Volume 3 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women

  • Authors:
    • Abeer Al-Qasem
    • Mohamed Toulimat
    • Asma Tulbah
    • Naser Elkum
    • Taher Al-Tweigeri
    • Abdelilah Aboussekhra

  • View Affiliations / Copyright

    Affiliations: Department of Biological and Medical Research, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh 11211, KSA, Department of Pathology, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh 11211, KSA, Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh 11211, KSA, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh 11211, KSA
  • Pages: 875-878
    |
    Published online on: January 24, 2012
       https://doi.org/10.3892/ol.2012.581
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Abstract

Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we analyzed the possible link between TP53 single nucleotide polymorphisms (SNPs) and the risk of breast cancer in Saudi women by direct sequencing of the TP53 gene exon 4 from 100 breast cancer tissues. The proportion of the polymorphic forms of SNP72 in the Saudi breast cancer patients were: Arg/Arg (RR), 39%; Pro/Pro (PP), 36%; and Arg/Pro (RP), 25%. The frequencies of these forms in disease-free Saudi women were 7.59, 22.22 and 60.19%, respectively. This indicates that the RR form of the codon 72 polymorphism is a potential risk factor, whereas the RP form is a protection factor against breast cancer among Saudi women (p=0.0001). Moreover, the results have shown that the p53 R72P SNP is significantly associated with the early onset of breast cancer in the Saudi population (p=0.0138). However, the codon 47 polymorphism appears to have no role in this disease among Saudi women. These results indicate that the TP53 gene could play a major role in breast carcinogenesis and the early onset of the disease among Saudi women.

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Copy and paste a formatted citation
Spandidos Publications style
Al-Qasem A, Toulimat M, Tulbah A, Elkum N, Al-Tweigeri T and Aboussekhra A: The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women. Oncol Lett 3: 875-878, 2012.
APA
Al-Qasem, A., Toulimat, M., Tulbah, A., Elkum, N., Al-Tweigeri, T., & Aboussekhra, A. (2012). The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women. Oncology Letters, 3, 875-878. https://doi.org/10.3892/ol.2012.581
MLA
Al-Qasem, A., Toulimat, M., Tulbah, A., Elkum, N., Al-Tweigeri, T., Aboussekhra, A."The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women". Oncology Letters 3.4 (2012): 875-878.
Chicago
Al-Qasem, A., Toulimat, M., Tulbah, A., Elkum, N., Al-Tweigeri, T., Aboussekhra, A."The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women". Oncology Letters 3, no. 4 (2012): 875-878. https://doi.org/10.3892/ol.2012.581
Copy and paste a formatted citation
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Spandidos Publications style
Al-Qasem A, Toulimat M, Tulbah A, Elkum N, Al-Tweigeri T and Aboussekhra A: The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women. Oncol Lett 3: 875-878, 2012.
APA
Al-Qasem, A., Toulimat, M., Tulbah, A., Elkum, N., Al-Tweigeri, T., & Aboussekhra, A. (2012). The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women. Oncology Letters, 3, 875-878. https://doi.org/10.3892/ol.2012.581
MLA
Al-Qasem, A., Toulimat, M., Tulbah, A., Elkum, N., Al-Tweigeri, T., Aboussekhra, A."The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women". Oncology Letters 3.4 (2012): 875-878.
Chicago
Al-Qasem, A., Toulimat, M., Tulbah, A., Elkum, N., Al-Tweigeri, T., Aboussekhra, A."The p53 codon 72 polymorphism is associated with risk and early onset of breast cancer among Saudi women". Oncology Letters 3, no. 4 (2012): 875-878. https://doi.org/10.3892/ol.2012.581
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