Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer

  • Authors:
    • Guojun Zhang
    • Xudong Sun
    • Hong Lv
    • Xiaolin Yang
    • Xixiong Kang
  • View Affiliations

  • Published online on: January 30, 2012     https://doi.org/10.3892/ol.2012.584
  • Pages: 940-944
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Abstract

Previous studies reported that serum amyloid A (SAA) is elevated in patients with tumors, including breast cancer, compared to healthy controls. In addition, the levels of SAA increase gradually with tumor progression. In this study, we investigated the blood SAA level of breast cancer patients, and evaluated its potential as a serum biomarker for the early diagnosis of breast cancer and as a staging estimate. SAA protein was determined by enzyme-linked immunosorbent assay in serum samples from 30 healthy women, 21 women with benign diseases and 118 breast cancer patients who were subdivided into 4 groups based on their clinical characteristics. SAA levels were not statistically different in stage I breast cancer patients compared with the healthy controls and benign breast disease patients. SAA concentrations had medians of 0.63 µg/ml in normal healthy women, 0.76 µg/ml in patients with benign disease (p>0.05) and 0.82 µg/ml in stage I breast cancer patients (p>0.05). By contrast, SAA values in stage Ⅱ, Ⅲ and Ⅳ patients had a significantly higher median compared to those of the healthy, benign breast diseases and stage I groups (p<0.05). Breast cancer patients with lymph node (LN) metastasis or distant metastasis were found to have significantly higher SAA concentrations than those without metastases. SAA is not a suitable marker for early breast cancer diagnosis, but its level is correlated with the stage of breast cancer. Thus, it may be a good candidate marker for the staging and prognosis of breast cancer.

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April 2012
Volume 3 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang G, Sun X, Lv H, Yang X and Kang X: Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer. Oncol Lett 3: 940-944, 2012
APA
Zhang, G., Sun, X., Lv, H., Yang, X., & Kang, X. (2012). Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer. Oncology Letters, 3, 940-944. https://doi.org/10.3892/ol.2012.584
MLA
Zhang, G., Sun, X., Lv, H., Yang, X., Kang, X."Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer". Oncology Letters 3.4 (2012): 940-944.
Chicago
Zhang, G., Sun, X., Lv, H., Yang, X., Kang, X."Serum amyloid A: A new potential serum marker correlated with the stage of breast cancer". Oncology Letters 3, no. 4 (2012): 940-944. https://doi.org/10.3892/ol.2012.584