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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April 2012 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo

  • Authors:
    • Lenka Koci
    • Katarina Chlebova
    • Martina Hyzdalova
    • Jirina Hofmanova
    • Miroslav Jira
    • Petr Kysela
    • Alois Kozubik
    • Zdenek Kala
    • Pavel Krejci

  • View Affiliations / Copyright

    Affiliations: Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic, Department of Animal Physiology and Immunology, Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic, Department of Surgery, Masaryk University Hospital, Brno, Czech Republic
  • Pages: 913-916
    |
    Published online on: February 3, 2012
       https://doi.org/10.3892/ol.2012.593
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Abstract

Apoptosis inhibitor 5 (API-5) is a 55 kDa nuclear protein with potent anti-apoptotic signaling in tumor cells in vitro. In this study, we analyzed the expression of the API-5 protein in vivo in a broad spectrum of human carcinomas, including those of the colon, lung, liver, kidney, pancreas, stomach and esophagus using tumor tissues obtained during tumor resection. The results showed significant upregulation of API-5 expression in biopsies of lung (23%, n=13) and colorectal tumors (33%, n=27) in comparison with biopsies from the adjacent normal tissue. Colon cancer biopsies were used to study the cell populations with an upregulated level of expression of API-5 more closely. Using a magnetic bead‑based selection for the epithelial cell marker EpCAM, we purified epithelial cells from the tumor and control tissues and analyzed these cells for API-5 expression by western immunoblotting. We observed that EpCAM-positive tumor cells expressed API-5 in all three colorectal cancer cases tested, in contrast to the control EpCAM-positive and EpCAM‑negative cells isolated from the control or tumor tissues. These data suggest that the expression of the API-5 protein is upregulated in tumor epithelial cells and may serve as a prognostic marker in colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Koci L, Chlebova K, Hyzdalova M, Hofmanova J, Jira M, Kysela P, Kozubik A, Kala Z and Krejci P: Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo. Oncol Lett 3: 913-916, 2012.
APA
Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P. ... Krejci, P. (2012). Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo. Oncology Letters, 3, 913-916. https://doi.org/10.3892/ol.2012.593
MLA
Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P., Kozubik, A., Kala, Z., Krejci, P."Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo". Oncology Letters 3.4 (2012): 913-916.
Chicago
Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P., Kozubik, A., Kala, Z., Krejci, P."Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo". Oncology Letters 3, no. 4 (2012): 913-916. https://doi.org/10.3892/ol.2012.593
Copy and paste a formatted citation
x
Spandidos Publications style
Koci L, Chlebova K, Hyzdalova M, Hofmanova J, Jira M, Kysela P, Kozubik A, Kala Z and Krejci P: Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo. Oncol Lett 3: 913-916, 2012.
APA
Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P. ... Krejci, P. (2012). Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo. Oncology Letters, 3, 913-916. https://doi.org/10.3892/ol.2012.593
MLA
Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P., Kozubik, A., Kala, Z., Krejci, P."Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo". Oncology Letters 3.4 (2012): 913-916.
Chicago
Koci, L., Chlebova, K., Hyzdalova, M., Hofmanova, J., Jira, M., Kysela, P., Kozubik, A., Kala, Z., Krejci, P."Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo". Oncology Letters 3, no. 4 (2012): 913-916. https://doi.org/10.3892/ol.2012.593
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