IL‑8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells

  • Authors:
    • Linlin Jia
    • Fengying Li
    • Mingliang Shao
    • Wei Zhang
    • Chunbin Zhang
    • Xiaolian Zhao
    • Haiyan Luan
    • Yaling Qi
    • Pengxia Zhang
    • Lichun Liang
    • Xiuyue Jia
    • Kun Zhang
    • Yan Lu
    • Zhe Yang
    • Xiulin Zhu
    • Qi Zhang
    • Jiwei Du
    • Weiqun Wang
  • View Affiliations

  • Published online on: November 10, 2017     https://doi.org/10.3892/ol.2017.7391
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Abstract

Interleukin‑8 (IL‑8) serves an important function in chronic inflammation and cancer development; however, the underlying molecular mechanism(s) of IL‑8 in uterine cervical cancer remains unclear. The present study investigated whether IL‑8 and its receptors [IL‑8 receptor (IL‑8R)A and IL‑8RB] contributed to the proliferative and migratory abilities of HeLa cervical cancer cells, and also investigated the potential underlying molecular mechanisms. Results demonstrated that IL‑8 and its receptors were detected in HeLa cells, and levels of IL‑8RA were significantly increased compared with those of IL‑8RB. Furthermore, the level of IL‑8 in cervical cancer tissues was significantly increased compared with that in normal uterine cervical tissues, and migratory and proliferative efficiencies of HeLa cells treated with exogenous IL‑8 were increased, compared with untreated HeLa cells. In addition, exogenous IL‑8 was able to downregulate endocytic adaptor protein (NUMB), and upregulate IL‑8RA, IL‑8RB and extracellular signal‑regulated protein kinases (ERKs) expression levels in HeLa cells. Results suggest that IL‑8 and its receptors were associated with the tumorigenesis of uterine cervical cancer, and exogenous IL‑8 promotes the carcinogenic potential of HeLa cells by increasing the expression levels of IL‑8RA, IL‑8RB and ERK, and decreasing the expression level of NUMB.

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Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Jia, L., Li, F., Shao, M., Zhang, W., Zhang, C., Zhao, X. ... Wang, W. (1899). IL‑8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells. Oncology Letters, 0, 0-0. https://doi.org/10.3892/ol.2017.7391
MLA
Jia, L., Li, F., Shao, M., Zhang, W., Zhang, C., Zhao, X., Luan, H., Qi, Y., Zhang, P., Liang, L., Jia, X., Zhang, K., Lu, Y., Yang, Z., Zhu, X., Zhang, Q., Du, J., Wang, W."IL‑8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells". Oncology Letters 0.0 (1899): 0-0.
Chicago
Jia, L., Li, F., Shao, M., Zhang, W., Zhang, C., Zhao, X., Luan, H., Qi, Y., Zhang, P., Liang, L., Jia, X., Zhang, K., Lu, Y., Yang, Z., Zhu, X., Zhang, Q., Du, J., Wang, W."IL‑8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells". Oncology Letters 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ol.2017.7391