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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-2018 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-2018 Volume 15 Issue 5

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Article

Perineural invasion in early-stage cervical cancer and its relevance following surgery

  • Authors:
    • Yi Zhu
    • Guonan Zhang
    • Yan Yang
    • Ling Cui
    • Shijun Jia
    • Yu Shi
    • Shuiqin Song
    • Shiqiang Xu

  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, Sichuan Cancer Hospital & Institute, Cancer Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China, Graduate School, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China, Department of Pathology, Sichuan Cancer Hospital & Institute, Cancer Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China
  • Pages: 6555-6561
    |
    Published online on: February 26, 2018
       https://doi.org/10.3892/ol.2018.8116
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Abstract

Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that has attracted attention as a novel prognostic factor for cancer. The present study aimed to investigate the prognostic value of PNI in patients with early‑stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2‑IIA). A total of 210 patients who underwent radical hysterectomy and pelvic lymphadenectomy between 2007 and 2012 were included in the current study, of whom 8.57% (18/210) exhibited PNI. Patients with PNI were more likely to exhibit adverse histopathological features, such as increased tumor size, depth of stromal invasion, parametrial invasion, lymphovascular space invasion and lymph nodes metastases (all P<0.05). Patients with PNI exhibited shorter disease‑free and overall survival (P=0.002 and P=0.017, respectively). However, PNI was not identified as an independent risk factor for either recurrence or death by multivariate analysis. Furthermore, 88.9% (16/18) of patients with PNI received adjuvant therapy following surgery. PNI was significantly associated with well‑established indicators for adjuvant therapy. In conclusion, PNI was associated with multiple high‑risk factors and its presence was indicative of a poor outcome in patients with early‑stage cervical cancer, which may influence management decisions regarding adjuvant therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Zhang G, Yang Y, Cui L, Jia S, Shi Y, Song S and Xu S: Perineural invasion in early-stage cervical cancer and its relevance following surgery. Oncol Lett 15: 6555-6561, 2018.
APA
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y. ... Xu, S. (2018). Perineural invasion in early-stage cervical cancer and its relevance following surgery. Oncology Letters, 15, 6555-6561. https://doi.org/10.3892/ol.2018.8116
MLA
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y., Song, S., Xu, S."Perineural invasion in early-stage cervical cancer and its relevance following surgery". Oncology Letters 15.5 (2018): 6555-6561.
Chicago
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y., Song, S., Xu, S."Perineural invasion in early-stage cervical cancer and its relevance following surgery". Oncology Letters 15, no. 5 (2018): 6555-6561. https://doi.org/10.3892/ol.2018.8116
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Zhang G, Yang Y, Cui L, Jia S, Shi Y, Song S and Xu S: Perineural invasion in early-stage cervical cancer and its relevance following surgery. Oncol Lett 15: 6555-6561, 2018.
APA
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y. ... Xu, S. (2018). Perineural invasion in early-stage cervical cancer and its relevance following surgery. Oncology Letters, 15, 6555-6561. https://doi.org/10.3892/ol.2018.8116
MLA
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y., Song, S., Xu, S."Perineural invasion in early-stage cervical cancer and its relevance following surgery". Oncology Letters 15.5 (2018): 6555-6561.
Chicago
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y., Song, S., Xu, S."Perineural invasion in early-stage cervical cancer and its relevance following surgery". Oncology Letters 15, no. 5 (2018): 6555-6561. https://doi.org/10.3892/ol.2018.8116
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