Perineural invasion in early-stage cervical cancer and its relevance following surgery

  • Authors:
    • Yi Zhu
    • Guonan Zhang
    • Yan Yang
    • Ling Cui
    • Shijun Jia
    • Yu Shi
    • Shuiqin Song
    • Shiqiang Xu
  • View Affiliations

  • Published online on: February 26, 2018     https://doi.org/10.3892/ol.2018.8116
  • Pages: 6555-6561
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Abstract

Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that has attracted attention as a novel prognostic factor for cancer. The present study aimed to investigate the prognostic value of PNI in patients with early‑stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2‑IIA). A total of 210 patients who underwent radical hysterectomy and pelvic lymphadenectomy between 2007 and 2012 were included in the current study, of whom 8.57% (18/210) exhibited PNI. Patients with PNI were more likely to exhibit adverse histopathological features, such as increased tumor size, depth of stromal invasion, parametrial invasion, lymphovascular space invasion and lymph nodes metastases (all P<0.05). Patients with PNI exhibited shorter disease‑free and overall survival (P=0.002 and P=0.017, respectively). However, PNI was not identified as an independent risk factor for either recurrence or death by multivariate analysis. Furthermore, 88.9% (16/18) of patients with PNI received adjuvant therapy following surgery. PNI was significantly associated with well‑established indicators for adjuvant therapy. In conclusion, PNI was associated with multiple high‑risk factors and its presence was indicative of a poor outcome in patients with early‑stage cervical cancer, which may influence management decisions regarding adjuvant therapy.

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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhu Y, Zhang G, Yang Y, Cui L, Jia S, Shi Y, Song S and Xu S: Perineural invasion in early-stage cervical cancer and its relevance following surgery. Oncol Lett 15: 6555-6561, 2018
APA
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y. ... Xu, S. (2018). Perineural invasion in early-stage cervical cancer and its relevance following surgery. Oncology Letters, 15, 6555-6561. https://doi.org/10.3892/ol.2018.8116
MLA
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y., Song, S., Xu, S."Perineural invasion in early-stage cervical cancer and its relevance following surgery". Oncology Letters 15.5 (2018): 6555-6561.
Chicago
Zhu, Y., Zhang, G., Yang, Y., Cui, L., Jia, S., Shi, Y., Song, S., Xu, S."Perineural invasion in early-stage cervical cancer and its relevance following surgery". Oncology Letters 15, no. 5 (2018): 6555-6561. https://doi.org/10.3892/ol.2018.8116