Open Access

Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis

  • Authors:
    • Ilda Patrícia Ribeiro
    • Francisco Caramelo
    • Margarida Ribeiro
    • Ana Machado
    • Jorge Miguéis
    • Francisco Marques
    • Isabel Marques Carreira
    • Joana Barbosa Melo
  • View Affiliations

  • Published online on: March 12, 2020     https://doi.org/10.3892/ol.2020.11459
  • Pages: 3459-3468
  • Copyright: © Ribeiro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite the increased molecular knowledge and the diagnostic and therapeutic improvements, the survival of patients with upper aerodigestive tract carcinoma remains poor. The identification of early diagnostic and prognostic biomarkers and the development of molecular models to distinguish patients that will recur and/or develop metastasis after treatment as well as to benefit with target therapies can be important to decrease mortality, improve survival rates and improve the quality of life of these patients. The current study analyzed 21 upper aerodigestive tract carcinomas through array comparative genomic hybridization and methylation‑specific multiplex ligation‑dependent probe amplification techniques. A number of chromosomal regions and genes were observed with copy number alterations and methylation. A predictive (epi)genomic model that comprises the 3p chromosomal region and WT1, VHL and THBS1 genes was built, highlighting a molecular signature with possible clinical use. The current study may aid in the development of a more individualized patient management and targeted drug design. The power of this genomic and epigenetic model to predict the recurrence and metastasis development should be evaluated and validated in future larger cohort study.

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May 2020
Volume 19 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Ribeiro, I.P., Caramelo, F., Ribeiro, M., Machado, A., Miguéis, J., Marques, F. ... Melo, J.B. (2020). Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis. Oncology Letters, 19, 3459-3468. https://doi.org/10.3892/ol.2020.11459
MLA
Ribeiro, I. P., Caramelo, F., Ribeiro, M., Machado, A., Miguéis, J., Marques, F., Carreira, I. M., Melo, J. B."Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis". Oncology Letters 19.5 (2020): 3459-3468.
Chicago
Ribeiro, I. P., Caramelo, F., Ribeiro, M., Machado, A., Miguéis, J., Marques, F., Carreira, I. M., Melo, J. B."Upper aerodigestive tract carcinoma: Development of a (epi)genomic predictive model for recurrence and metastasis". Oncology Letters 19, no. 5 (2020): 3459-3468. https://doi.org/10.3892/ol.2020.11459