Open Access

Simultaneous multiple myeloma and non‑small cell lung carcinoma: A case report and review of the literature

  • Authors:
    • Huan-Huan Dong
    • Jing Li
    • Lin Kang
    • Qiang Wei
    • Yan Li
  • View Affiliations

  • Published online on: May 3, 2022     https://doi.org/10.3892/ol.2022.13315
  • Article Number: 195
  • Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Multiple myeloma (MM) is the second commonest hematologic malignancy. Synchronous presentation of MM and lung cancer is a rare occurrence. The present study reports a case of MM combined with lung cancer and reviews previously reported cases of the co‑existence of non‑small cell lung carcinoma and MM. At Hebei General Hospital (Shijiazhuang, China), a 52‑year‑man was diagnosed with MM complicated by lung lesion. Lung computed tomography (CT) showed an increase in lesion density after the second cycle of chemotherapy. The lesion was surgically removed and the patient was diagnosed with non‑small cell lung carcinoma by lung biopsy pathology. After the fifth cycle of VDT (bortezomib, dexamethasone and thalidomide), the patient received autologous stem cell transplantation. Immunohistochemical staining for CD38, CD138, CD39, CD203a and TNF‑α were positive in both MM and lung cancer; CD73 was only positive in lung cancer. The present study described the rare event of the simultaneous occurrence of MM and lung adenocarcinoma and discussed the potential link between the two tumors. CD38 may play a role in MM and lung cancer by changing the bone marrow microenvironment through adenosine.

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June-2022
Volume 23 Issue 6

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Copy and paste a formatted citation
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Spandidos Publications style
Dong H, Li J, Kang L, Wei Q and Li Y: Simultaneous multiple myeloma and non‑small cell lung carcinoma: A case report and review of the literature. Oncol Lett 23: 195, 2022
APA
Dong, H., Li, J., Kang, L., Wei, Q., & Li, Y. (2022). Simultaneous multiple myeloma and non‑small cell lung carcinoma: A case report and review of the literature. Oncology Letters, 23, 195. https://doi.org/10.3892/ol.2022.13315
MLA
Dong, H., Li, J., Kang, L., Wei, Q., Li, Y."Simultaneous multiple myeloma and non‑small cell lung carcinoma: A case report and review of the literature". Oncology Letters 23.6 (2022): 195.
Chicago
Dong, H., Li, J., Kang, L., Wei, Q., Li, Y."Simultaneous multiple myeloma and non‑small cell lung carcinoma: A case report and review of the literature". Oncology Letters 23, no. 6 (2022): 195. https://doi.org/10.3892/ol.2022.13315