Open Access

Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer

  • Authors:
    • Levent Emirzeoglu
    • Ozgur Olmez
    • Fatma Nihan Akkoc Mustafayev
    • Ufuk Berber
    • Ismail Yilmaz
    • Serkan Celik
    • Bala Basak Oven
    • Mehmet Alpaslan Ozgun
  • View Affiliations

  • Published online on: May 26, 2022     https://doi.org/10.3892/ol.2022.13347
  • Article Number: 226
  • Copyright: © Emirzeoglu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aberrant expression of human leukocyte antigen G (HLA‑G), an immunosuppressive molecule, has been observed in various cancer types. The exact mechanism of HLA‑G expression is unclear. HLA‑G expression is associated with low expression levels of microRNA (miR)‑148a and miR‑152. To the best of our knowledge, the prognostic value of the expression levels of miR‑148a, miR‑152 and HLA‑G has not been investigated in colon cancer. The aim of the present study was to investigate the relationship between the presence of HLA‑G molecules and the expression levels of miR‑148 and miR‑152 in colon cancer. In addition, the association of both HLA‑G and miR expression with survival results and clinicopathological data was determined. An immunohistochemical method was used for detection of HLA‑G expression in the tumor tissues and adjacent healthy tissues of 108 patients with colon cancer. Reverse transcription‑quantitative PCR was used for miR analysis. HLA‑G was expressed in 82 (75.9%) of the cancer samples, and there was no staining in normal tissues. HLA‑G expression >20%, which was found in 41.7% (45/108) of the patients with colon cancer, was significantly positively associated with patient survival (P=0.039). Additionally, miR‑148a levels were lower in the tumor tissues compared with the adjacent healthy tissues. No differences were found for miR‑152 expression. In addition, mir‑148a levels were found to be significantly lower (P=0.001) in HLA‑G‑positive tumor tissues than HLA‑G‑negative tumor tissues, but no such relationship was found for miR‑152 levels. The presence of HLA‑G expression was associated with poor survival outcomes. HLA‑G is one of the prognostic factors in colon cancer, and decreased miR‑148a expression in colon cancer tissues may be associated with HLA‑G‑mediated carcinogenesis.

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July-2022
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Spandidos Publications style
Emirzeoglu L, Olmez O, Mustafayev FN, Berber U, Yilmaz I, Celik S, Oven BB and Ozgun MA: Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer. Oncol Lett 24: 226, 2022
APA
Emirzeoglu, L., Olmez, O., Mustafayev, F.N., Berber, U., Yilmaz, I., Celik, S. ... Ozgun, M.A. (2022). Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer. Oncology Letters, 24, 226. https://doi.org/10.3892/ol.2022.13347
MLA
Emirzeoglu, L., Olmez, O., Mustafayev, F. N., Berber, U., Yilmaz, I., Celik, S., Oven, B. B., Ozgun, M. A."Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer". Oncology Letters 24.1 (2022): 226.
Chicago
Emirzeoglu, L., Olmez, O., Mustafayev, F. N., Berber, U., Yilmaz, I., Celik, S., Oven, B. B., Ozgun, M. A."Prognostic value of expression levels of miR‑148a, miR‑152 and HLA‑G in colon cancer". Oncology Letters 24, no. 1 (2022): 226. https://doi.org/10.3892/ol.2022.13347