Open Access

Comparing dosimetric and cancer control outcomes after intensity‑modulated radiation therapy and tomotherapy for advanced cervical cancer

  • Authors:
    • Dapeng Li
    • Dandan Wang
    • Shuai Feng
    • Quancai Chen
    • Xiugui Sheng
    • Jue Jia
    • Xiaohui Yan
    • Jian Zhu
    • Yueju Yin
  • View Affiliations

  • Published online on: May 31, 2022     https://doi.org/10.3892/ol.2022.13359
  • Article Number: 239
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Concurrent chemoradiation therapy (CCRT) is the standard treatment for locally advanced cervical cancer. The present study aimed to compare the therapeutic responses, toxicities and dosimetric parameters between intensity‑modulated radiation therapy (IMRT) and tomotherapy (TOMO) in patients with advanced cervical cancer. This retrospective study included 310 patients with stage IIB‑IIIB cervical cancer who underwent CCRT, with 155 patients in each group. Intracavitary brachytherapy was performed after a course of external beam radiation therapy (EBRT), or in the last week of pelvic EBRT. The treatment planning aim at point A (defined as a reference location 2 cm above the vaginal fornix and 2 cm beside the mid axis of the uterus) was >85 Gy in an equivalent dose at 2 Gy. There was no statistical difference with regard to clinicopathological characteristics between the two groups (P>0.05). Improved dose conformity and dose homogeneity (P<0.05) were observed in TOMO planning. TOMO provided more efficacious critical organ sparing than IMRT when assessing the percentage of normal tissue receiving at least 20 Gy (V20) for the bladder, the percentage of normal tissue receiving at least 40 Gy (V40) for the femoral head, and the V40 and V20 for the rectum (P<0.05). TOMO demonstrated a greater ability to protect the ovary (P<0.05). The acute radiation toxicity of proctitis and leukopenia were significantly lower in the TOMO group (P<0.05). The chronic radiation toxicity of radiation enterocolitis and cystitis was lower in the TOMO group (P<0.05). Thus, TOMO provided better critical organ sparing than IMRT. The radiation toxicities were acceptable. Therefore, TOMO appears to be a good option for the treatment of stage IIB‑IIIB cervical cancer.

Related Articles

Journal Cover

July-2022
Volume 24 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Wang D, Feng S, Chen Q, Sheng X, Jia J, Yan X, Zhu J and Yin Y: Comparing dosimetric and cancer control outcomes after intensity‑modulated radiation therapy and tomotherapy for advanced cervical cancer. Oncol Lett 24: 239, 2022
APA
Li, D., Wang, D., Feng, S., Chen, Q., Sheng, X., Jia, J. ... Yin, Y. (2022). Comparing dosimetric and cancer control outcomes after intensity‑modulated radiation therapy and tomotherapy for advanced cervical cancer. Oncology Letters, 24, 239. https://doi.org/10.3892/ol.2022.13359
MLA
Li, D., Wang, D., Feng, S., Chen, Q., Sheng, X., Jia, J., Yan, X., Zhu, J., Yin, Y."Comparing dosimetric and cancer control outcomes after intensity‑modulated radiation therapy and tomotherapy for advanced cervical cancer". Oncology Letters 24.1 (2022): 239.
Chicago
Li, D., Wang, D., Feng, S., Chen, Q., Sheng, X., Jia, J., Yan, X., Zhu, J., Yin, Y."Comparing dosimetric and cancer control outcomes after intensity‑modulated radiation therapy and tomotherapy for advanced cervical cancer". Oncology Letters 24, no. 1 (2022): 239. https://doi.org/10.3892/ol.2022.13359