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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2026 Volume 32 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Case Report

Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report

  • Authors:
    • Nobuhito Hara
    • Rika Sasaki
    • Yoshiki Kojitani
    • Yumi Yoshii
    • Masahide Ota
    • Shunsuke Okazaki
    • Shinichi Ochi
    • Ryo Miyata
    • Masatsugu Hamaji
    • Sayaka Ando
    • Maiko Takeda
    • Akihiko Yoshizawa
    • Masayuki Takeda

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Genomics and Medical Oncology, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Department of Hematology, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara 634‑8521, Japan
  • Article Number: 354
    |
    Published online on: June 16, 2026
       https://doi.org/10.3892/ol.2026.15709
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Abstract

Pure red cell aplasia (PRCA) is a rare paraneoplastic complication occurring in ~5% of patients with thymoma. The optimal management of metastatic thymoma complicated by PRCA remains unclear, particularly when immediate immunosuppressive therapy is not feasible. The present report describes the case of a 69‑year‑old man with type AB thymoma accompanied by multiple bilateral pulmonary metastases (cT1bN0M1b, stage IVB) and severe transfusion‑dependent PRCA. Because the tumor was unresectable at presentation, systemic chemotherapy with the ADOC regimen (doxorubicin, cisplatin, vincristine and cyclophosphamide) was initiated. Prior to chemotherapy, daily blood transfusions were needed, but after the first cycle, this need was decreased, with transfusion intervals prolonged to every 7‑17 days. On radiographic evaluation, there was sustained tumor reduction with stable disease. After six cycles of chemotherapy, cyclosporine was introduced and robot‑assisted thymectomy was subsequently performed. A total of 2 weeks after initiating cyclosporine, the patient achieved transfusion independence with recovery of hemoglobin and reticulocyte counts. Therefore, cytotoxic chemotherapy may contribute to both tumor control and improvement of PRCA in metastatic thymoma, although further clinical evidence is required to establish optimal therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Hara N, Sasaki R, Kojitani Y, Yoshii Y, Ota M, Okazaki S, Ochi S, Miyata R, Hamaji M, Ando S, Ando S, et al: Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report. Oncol Lett 32: 354, 2026.
APA
Hara, N., Sasaki, R., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S. ... Takeda, M. (2026). Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report. Oncology Letters, 32, 354. https://doi.org/10.3892/ol.2026.15709
MLA
Hara, N., Sasaki, R., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Ochi, S., Miyata, R., Hamaji, M., Ando, S., Takeda, M., Yoshizawa, A., Takeda, M."Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report". Oncology Letters 32.2 (2026): 354.
Chicago
Hara, N., Sasaki, R., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Ochi, S., Miyata, R., Hamaji, M., Ando, S., Takeda, M., Yoshizawa, A., Takeda, M."Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report". Oncology Letters 32, no. 2 (2026): 354. https://doi.org/10.3892/ol.2026.15709
Copy and paste a formatted citation
x
Spandidos Publications style
Hara N, Sasaki R, Kojitani Y, Yoshii Y, Ota M, Okazaki S, Ochi S, Miyata R, Hamaji M, Ando S, Ando S, et al: Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report. Oncol Lett 32: 354, 2026.
APA
Hara, N., Sasaki, R., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S. ... Takeda, M. (2026). Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report. Oncology Letters, 32, 354. https://doi.org/10.3892/ol.2026.15709
MLA
Hara, N., Sasaki, R., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Ochi, S., Miyata, R., Hamaji, M., Ando, S., Takeda, M., Yoshizawa, A., Takeda, M."Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report". Oncology Letters 32.2 (2026): 354.
Chicago
Hara, N., Sasaki, R., Kojitani, Y., Yoshii, Y., Ota, M., Okazaki, S., Ochi, S., Miyata, R., Hamaji, M., Ando, S., Takeda, M., Yoshizawa, A., Takeda, M."Initial chemotherapy decreases transfusion dependence and enables definitive therapy in metastatic thymoma complicated by pure red cell aplasia: A case report". Oncology Letters 32, no. 2 (2026): 354. https://doi.org/10.3892/ol.2026.15709
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