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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March-April 2010 Volume 1 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum

  • Authors:
    • Jiqiang Liu
    • Zhenya Zhang
    • Guoqing Xing
    • Honghai Hu
    • Norio Sugiura
    • Intabon Keo

  • View Affiliations / Copyright

    Affiliations: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba 305-8572, Japan
  • Pages: 383-387
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/ol_00000068
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Abstract

In this study, for the first time, the possible antioxidant and antiproliferative activities of a hot-water extract (TW100) from the root of Tonh khidum (Actinidia kolomikta Maxim) were examined in vitro. Total phenolic compound, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and superoxide dismutase (SOD)-like activity assays were utilized to investigate its antioxidant activity. As a result, TW100 showed a strong antioxidant activity. The total phenolic content of TW100 was 143 µg gallic acid equivalents/mg. The SOD-like activity of TW100 was 666,667 U/g extract, and the DPPH radical-scavenging activity was 129 µg/ml at EC50 which was one third of vitamin E (40 µg/ml). The antiproliferative effects and ability of the extracts to induce apoptosis were studied in vitro using human cervical cancer ME-180 cells. Results showed that TW100 inhibited the proliferation of ME-180 cells in a dose- and time-dependent manner except at a low concentration (10 µg/ml) with an EC50 at 24, 48 and 72 h of 36.28, 30.55 and 29.78 µg/ml, respectively. TW100 also induced apoptosis as determined by a nuclear fragmentation assay and an analysis of flow cytometry. In conclusion, the hot-water extract from the root of Tonh khidum possesses potential antioxidant and antiproliferative activities.

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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Zhang Z, Xing G, Hu H, Sugiura N and Keo I: Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum . Oncol Lett 1: 383-387, 2010.
APA
Liu, J., Zhang, Z., Xing, G., Hu, H., Sugiura, N., & Keo, I. (2010). Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum . Oncology Letters, 1, 383-387. https://doi.org/10.3892/ol_00000068
MLA
Liu, J., Zhang, Z., Xing, G., Hu, H., Sugiura, N., Keo, I."Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum ". Oncology Letters 1.2 (2010): 383-387.
Chicago
Liu, J., Zhang, Z., Xing, G., Hu, H., Sugiura, N., Keo, I."Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum ". Oncology Letters 1, no. 2 (2010): 383-387. https://doi.org/10.3892/ol_00000068
Copy and paste a formatted citation
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Spandidos Publications style
Liu J, Zhang Z, Xing G, Hu H, Sugiura N and Keo I: Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum . Oncol Lett 1: 383-387, 2010.
APA
Liu, J., Zhang, Z., Xing, G., Hu, H., Sugiura, N., & Keo, I. (2010). Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum . Oncology Letters, 1, 383-387. https://doi.org/10.3892/ol_00000068
MLA
Liu, J., Zhang, Z., Xing, G., Hu, H., Sugiura, N., Keo, I."Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum ". Oncology Letters 1.2 (2010): 383-387.
Chicago
Liu, J., Zhang, Z., Xing, G., Hu, H., Sugiura, N., Keo, I."Potential antioxidant and antiproliferative activities of a hot-water extract from the root of Tonh khidum ". Oncology Letters 1, no. 2 (2010): 383-387. https://doi.org/10.3892/ol_00000068
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