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SHEDDING OF TNF-RECEPTOR AND SOLUBLE ICAM-1 MOLECULES IN RESPONSE TO TREATMENT WITH RECOMBINANT TNF-ALPHA AND IFN-GAMMA IN PATIENTS WITH COLORECTAL-CANCER

  • Authors:
    • W ZELLER
    • W FIEDLER
    • CJ PEIMANN
    • B SCHAFER
    • DK HOSSFELD

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  • Published online on: January 1, 1994     https://doi.org/10.3892/or.1.1.13
  • Pages: 13-16
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor alpha receptor (TNF-R) have been detected in soluble forms in the serum of cancer patients. sICAM-1 can abrogate non MHC-restricted cytotoxicity mediated by NK and lymphokine-activated killer cells. Soluble TNF-alpha receptors have been shown to neutralize the cytopathic activity of recombinant TNF-alpha. Both mechanisms can facilitate neoplastic cells to escape immunosurveillance. Serum levels of sTNF-R and sICAM-1 were determined during a phase II combination trial with TNF-alpha and IFN-gamma in eight patients with colorectal cancer. Serum concentrations of sTNF-R and sICAM-1 increased significantly during the treatment period. Shedding of ICAM-1 and TNF-R induced by TNF-alpha and IFN-gamma could be responsible for the ineffectivity of TNF-alpha based treatment regimens.

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January 1994
Volume 1 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
ZELLER W, FIEDLER W, PEIMANN C, SCHAFER B and HOSSFELD D: SHEDDING OF TNF-RECEPTOR AND SOLUBLE ICAM-1 MOLECULES IN RESPONSE TO TREATMENT WITH RECOMBINANT TNF-ALPHA AND IFN-GAMMA IN PATIENTS WITH COLORECTAL-CANCER. Oncol Rep 1: 13-16, 1994
APA
ZELLER, W., FIEDLER, W., PEIMANN, C., SCHAFER, B., & HOSSFELD, D. (1994). SHEDDING OF TNF-RECEPTOR AND SOLUBLE ICAM-1 MOLECULES IN RESPONSE TO TREATMENT WITH RECOMBINANT TNF-ALPHA AND IFN-GAMMA IN PATIENTS WITH COLORECTAL-CANCER. Oncology Reports, 1, 13-16. https://doi.org/10.3892/or.1.1.13
MLA
ZELLER, W., FIEDLER, W., PEIMANN, C., SCHAFER, B., HOSSFELD, D."SHEDDING OF TNF-RECEPTOR AND SOLUBLE ICAM-1 MOLECULES IN RESPONSE TO TREATMENT WITH RECOMBINANT TNF-ALPHA AND IFN-GAMMA IN PATIENTS WITH COLORECTAL-CANCER". Oncology Reports 1.1 (1994): 13-16.
Chicago
ZELLER, W., FIEDLER, W., PEIMANN, C., SCHAFER, B., HOSSFELD, D."SHEDDING OF TNF-RECEPTOR AND SOLUBLE ICAM-1 MOLECULES IN RESPONSE TO TREATMENT WITH RECOMBINANT TNF-ALPHA AND IFN-GAMMA IN PATIENTS WITH COLORECTAL-CANCER". Oncology Reports 1, no. 1 (1994): 13-16. https://doi.org/10.3892/or.1.1.13