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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1994 Volume 1 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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January 1994 Volume 1 Issue 1

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TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED

  • Authors:
    • N LAVISTA
    • F PIU
    • L LOISEAU
    • G BRUN
    • M CASTELLAZZI

  • View Affiliations / Copyright

    Affiliations: ECOLE NORMALE SUPER LYON,BIOL MOLEC & CELLULAR LAB,CNRS,UMR 49,F-69364 LYON 07,FRANCE.
  • Pages: 185-190
    |
    Published online on: January 1, 1994
       https://doi.org/10.3892/or.1.1.185
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Abstract

Proto-oncogene c-jun transforms primary chick embryo fibroblasts as a single gene when expressed from the replication competent retrovirus R (or RCAS). We have investigated whether transformation is caused by accumulating mutations within the proto-oncogene sequence during the retrotranscription process. c-jun coding sequences carried by three independently isolated R-cJUN viruses have been cloned and entirely sequenced. Two of these-were shown to carry no mutation demonstrating that deregulated expression of a normal c-Jun product is sufficient for transformation. On the contrary when expressed from non replicative Rneo vector lacking gag and pol sequences, the avian c-jun no longer transformed. This difference is correlated with weaker c-Jun accumulation in the second case. When expressed from the same Rneo vector, low level of v-Jun or of the heterologous mouse c-Jun still transform. Taken together, these data strongly suggest that a threshold level of c-Jun product is required for transformation and that this critical level can be lowered by mutations in c-jun or by the synthesis of an heterologous protein.

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Copy and paste a formatted citation
Spandidos Publications style
LAVISTA N, PIU F, LOISEAU L, BRUN G and CASTELLAZZI M: TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED. Oncol Rep 1: 185-190, 1994.
APA
LAVISTA, N., PIU, F., LOISEAU, L., BRUN, G., & CASTELLAZZI, M. (1994). TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED. Oncology Reports, 1, 185-190. https://doi.org/10.3892/or.1.1.185
MLA
LAVISTA, N., PIU, F., LOISEAU, L., BRUN, G., CASTELLAZZI, M."TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED". Oncology Reports 1.1 (1994): 185-190.
Chicago
LAVISTA, N., PIU, F., LOISEAU, L., BRUN, G., CASTELLAZZI, M."TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED". Oncology Reports 1, no. 1 (1994): 185-190. https://doi.org/10.3892/or.1.1.185
Copy and paste a formatted citation
x
Spandidos Publications style
LAVISTA N, PIU F, LOISEAU L, BRUN G and CASTELLAZZI M: TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED. Oncol Rep 1: 185-190, 1994.
APA
LAVISTA, N., PIU, F., LOISEAU, L., BRUN, G., & CASTELLAZZI, M. (1994). TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED. Oncology Reports, 1, 185-190. https://doi.org/10.3892/or.1.1.185
MLA
LAVISTA, N., PIU, F., LOISEAU, L., BRUN, G., CASTELLAZZI, M."TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED". Oncology Reports 1.1 (1994): 185-190.
Chicago
LAVISTA, N., PIU, F., LOISEAU, L., BRUN, G., CASTELLAZZI, M."TRANSFORMATION OF PRIMARY CHICK-EMBRYO FIBROBLASTS BY VIRALLY-EXPRESSED C-JUN REQUIRES NO MUTATION IN THE PROTEIN WHEN A SUFFICIENT LEVEL OF C-JUN PROTEIN IS REACHED". Oncology Reports 1, no. 1 (1994): 185-190. https://doi.org/10.3892/or.1.1.185
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