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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 1994 Volume 1 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 1994 Volume 1 Issue 1

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Article

DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY

  • Authors:
    • G FRANCHINI
    • A TUSEI
    • L BABILONTI
    • N DONADELLO
    • M FRANCHI
    • F ZANABONI
    • S TATEO
    • G MAZZINI
    • A RICCARDI
    • M DANOVA

  • View Affiliations / Copyright

    Affiliations: UNIV PAVIA,MED CLIN 2,I-27100 PAVIA,ITALY. UNIV PAVIA,OSTET GINECOL CLIN,I-27100 PAVIA,ITALY. IRCCS SAN MATTEO,PAVIA,ITALY. UNIV VARESE,OSTET GINECOL CLIN,VARESE,ITALY. CNR,CTR STUDIO ISTOCHIM,PAVIA,ITALY.
  • Pages: 65-67
    |
    Published online on: January 1, 1994
       https://doi.org/10.3892/or.1.1.65
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Abstract

We have studied the DNA ploidy and the proliferative activity in 102 patients with endometrial and cervical carcinoma, by flow cytometry. Samples were excised 1 hour after bromodeoxyuridine (BrdU, 250 mg/) e.v. infusion and fixed in 70% ethanol. Nuclear DNA content and BrdU incorporation, were simultaneously determined to obtain ploidy (DNA index) and proliferative activity (BrdU-labeling index, LI). No acute toxicity or side effects related to BrdU injection were recorded. The overall feasibility of the determinations was higher than 90% (93/102). Twenty-two out of 59 (37.2%) endometrial neoplasms and 23 out of 34 (67.6%) cervical neoplasms were aneuploid, with a median DNA-index of the aneuploid peak of 1.3 and 1.4, respectively. Overall median BrdU LIs were 4.8% and 7.2%. Proliferative activity was found to be higher in aneuploid tumors (p<.05). DNA ploidy and/or BrdU-LI were not significantly related either with the clinical stage or the histopathologic grading in either tumor type. The BrdU in vivo administration coupled with bivariate FCM for measurement is a simple method that can be performed in clinical settings to better evaluate the prognostic significance of proliferative parameters in gynecological tumors.

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Copy and paste a formatted citation
Spandidos Publications style
FRANCHINI G, TUSEI A, BABILONTI L, DONADELLO N, FRANCHI M, ZANABONI F, TATEO S, MAZZINI G, RICCARDI A, DANOVA M, DANOVA M, et al: DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY. Oncol Rep 1: 65-67, 1994.
APA
FRANCHINI, G., TUSEI, A., BABILONTI, L., DONADELLO, N., FRANCHI, M., ZANABONI, F. ... DANOVA, M. (1994). DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY. Oncology Reports, 1, 65-67. https://doi.org/10.3892/or.1.1.65
MLA
FRANCHINI, G., TUSEI, A., BABILONTI, L., DONADELLO, N., FRANCHI, M., ZANABONI, F., TATEO, S., MAZZINI, G., RICCARDI, A., DANOVA, M."DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY". Oncology Reports 1.1 (1994): 65-67.
Chicago
FRANCHINI, G., TUSEI, A., BABILONTI, L., DONADELLO, N., FRANCHI, M., ZANABONI, F., TATEO, S., MAZZINI, G., RICCARDI, A., DANOVA, M."DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY". Oncology Reports 1, no. 1 (1994): 65-67. https://doi.org/10.3892/or.1.1.65
Copy and paste a formatted citation
x
Spandidos Publications style
FRANCHINI G, TUSEI A, BABILONTI L, DONADELLO N, FRANCHI M, ZANABONI F, TATEO S, MAZZINI G, RICCARDI A, DANOVA M, DANOVA M, et al: DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY. Oncol Rep 1: 65-67, 1994.
APA
FRANCHINI, G., TUSEI, A., BABILONTI, L., DONADELLO, N., FRANCHI, M., ZANABONI, F. ... DANOVA, M. (1994). DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY. Oncology Reports, 1, 65-67. https://doi.org/10.3892/or.1.1.65
MLA
FRANCHINI, G., TUSEI, A., BABILONTI, L., DONADELLO, N., FRANCHI, M., ZANABONI, F., TATEO, S., MAZZINI, G., RICCARDI, A., DANOVA, M."DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY". Oncology Reports 1.1 (1994): 65-67.
Chicago
FRANCHINI, G., TUSEI, A., BABILONTI, L., DONADELLO, N., FRANCHI, M., ZANABONI, F., TATEO, S., MAZZINI, G., RICCARDI, A., DANOVA, M."DNA-PLOIDY AND PROLIFERATIVE ACTIVITY IN UTERINE-TUMORS - AN IN-VIVO STUDY USING BROMODEOXYURIDINE AND FLOW-CYTOMETRY". Oncology Reports 1, no. 1 (1994): 65-67. https://doi.org/10.3892/or.1.1.65
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