DIAGNOSTIC-SIGNIFICANCE OF LIVER-FAILURE AFTER NEWLY-APPEARED SERUM FRACTIONS FOLLOWING LIVER SURGERY
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- Published online on: March 1, 1994 https://doi.org/10.3892/or.1.2.457
- Pages: 457-460
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Abstract
We investigated a serum marker suggesting postoperative liver failure based on basic research. In diseased Long Evans Cinnamon rat with spontaneous development of hepatitis and hepatocellular carcinoma, the specific fractions, Fr 43 (peak-1) and Fr 58-60 (peak-2), newly appeared in the eluted serum following highperformance liquid chromatography. Peak-1 was associated with progressing Liver damage or failure. We applied this theory to five patients undergoing liver surgery and our expectations were realized. Peak-1 was probably a certain hepatic regenerating factor recognized in a previous study and we suspected that the exessive production of a liver regenerating factor signified an ongoing liver failure.
