DISTINCT SPECTRUM OF N-RAS MUTATIONS IN AML AND MDS PATIENTS IN YUGOSLAVIA

  • Authors:
    • K KRTOLICA
    • N UROSEVIC
    • D NESIC
    • L TUKIC
    • B DIMITRIJEVIC
    • A DUJIC
  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/or.1.3.619
  • Pages: 619-623
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Abstract

Mutations that activate ras genes were demonstrated to be associated with certain types of malignancies. Multiple point mutations were predominantly found in the N-ras and occasionally in the K-ras genes. The analysis of 4 MDS, 23 AML and 11 CML patients from Yugoslavia revealed the prevalence of the N-ras mutation (83%) over K-ras mutations (17%). Although the frequencies of the N- and K-ras mutations in these patients were similar to the ones reported for patients from USA and Japan, the N-ras mutational spectra considerably differed. The prevailing type of mutation in patients from Yugoslavia was G-to-T transversion at the first position in the codon 12 of the N-ras gene. This study supports a hypothesis that different geographical and environmental factors may cause the accumulation of different type of point mutations in the same target gene.

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May 1994
Volume 1 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
KRTOLICA K, UROSEVIC N, NESIC D, TUKIC L, DIMITRIJEVIC B and DUJIC A: DISTINCT SPECTRUM OF N-RAS MUTATIONS IN AML AND MDS PATIENTS IN YUGOSLAVIA. Oncol Rep 1: 619-623, 1994
APA
KRTOLICA, K., UROSEVIC, N., NESIC, D., TUKIC, L., DIMITRIJEVIC, B., & DUJIC, A. (1994). DISTINCT SPECTRUM OF N-RAS MUTATIONS IN AML AND MDS PATIENTS IN YUGOSLAVIA. Oncology Reports, 1, 619-623. https://doi.org/10.3892/or.1.3.619
MLA
KRTOLICA, K., UROSEVIC, N., NESIC, D., TUKIC, L., DIMITRIJEVIC, B., DUJIC, A."DISTINCT SPECTRUM OF N-RAS MUTATIONS IN AML AND MDS PATIENTS IN YUGOSLAVIA". Oncology Reports 1.3 (1994): 619-623.
Chicago
KRTOLICA, K., UROSEVIC, N., NESIC, D., TUKIC, L., DIMITRIJEVIC, B., DUJIC, A."DISTINCT SPECTRUM OF N-RAS MUTATIONS IN AML AND MDS PATIENTS IN YUGOSLAVIA". Oncology Reports 1, no. 3 (1994): 619-623. https://doi.org/10.3892/or.1.3.619