COMPARISON OF IFOSFAMIDE VERSUS CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN AND DOXORUBICIN (ADRIAMYCIN), AS FIRST-LINE THERAPY FOR ADVANCED EPITHELIAL OVARIAN-CANCER - REPORT OF A PILOT-STUDY

  • Authors:
    • RE HEMPLING
    • MS PIVER
    • TR BAKER
    • AM STANTON
    • DL DRISCOLL
  • View Affiliations

  • Published online on: May 1, 1994     https://doi.org/10.3892/or.1.3.631
  • Pages: 631-635
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Abstract

Cisplatin induction therapy followed by combination chemotherapy employing cisplatin, doxorubicin, and ifosfamide was administered to 25 consecutive patients with FIGO stage III:or IV epithelial ovarian cancer as first-line therapy following cytoreductive surgery. A median of seven (3-10) courses of combination chemotherapy were administered. Myelotoxicity necessitated dose attenuation in 20 (80%) patients. Microscopic hematuria was observed in one (4%) patient. Serious central neurotoxicity occurred in two (8%) patients. A surgically documentable response to therapy was observed in 16 of 19 (84%) patients who underwent second-look laparotomy. Thirteen (68%) patients had a surgical complete response, three (12%) patients had a surgical partial response, and three (12%) patients demonstrated progression of disease. The estimated two-year survival for the study population was 81%. The results observed in the current study were compared to those reported for a population of 40 patients with advanced ovarian cancer treated with cisplatin, doxorubicin, and cyclophosphamide (PAC). Patients treated with PAI had significantly (p=0.04) fewer episodes of sepsis, a significantly (p=0.02) greater percentage of patients requiring dose reduction secondary to myelotoxicity, and a significantly (p=0.02) higher surgical complete response rate. The two-year survival for patients treated with PAI of 81% and that for patients treated with PAC of 68%, do not differ significantly (p=0.39). The two-year disease-free survival for patients treated with PAI of 34% and the two-year disease-free survival of 55% for patients treated with PAC do not differ significantly (p=0.99). The combination of cisplatin, doxorubicin, and ifosfamide is effective as first-line therapy in the treatment of advanced epithelial ovarian cancer, but a significant advantage over the less costly standard regimen which employs cisplatin, doxorubicin and cyclophosphamide is not demonstrable in the current study.

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May 1994
Volume 1 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
HEMPLING R, PIVER M, BAKER T, STANTON A and DRISCOLL D: COMPARISON OF IFOSFAMIDE VERSUS CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN AND DOXORUBICIN (ADRIAMYCIN), AS FIRST-LINE THERAPY FOR ADVANCED EPITHELIAL OVARIAN-CANCER - REPORT OF A PILOT-STUDY. Oncol Rep 1: 631-635, 1994
APA
HEMPLING, R., PIVER, M., BAKER, T., STANTON, A., & DRISCOLL, D. (1994). COMPARISON OF IFOSFAMIDE VERSUS CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN AND DOXORUBICIN (ADRIAMYCIN), AS FIRST-LINE THERAPY FOR ADVANCED EPITHELIAL OVARIAN-CANCER - REPORT OF A PILOT-STUDY. Oncology Reports, 1, 631-635. https://doi.org/10.3892/or.1.3.631
MLA
HEMPLING, R., PIVER, M., BAKER, T., STANTON, A., DRISCOLL, D."COMPARISON OF IFOSFAMIDE VERSUS CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN AND DOXORUBICIN (ADRIAMYCIN), AS FIRST-LINE THERAPY FOR ADVANCED EPITHELIAL OVARIAN-CANCER - REPORT OF A PILOT-STUDY". Oncology Reports 1.3 (1994): 631-635.
Chicago
HEMPLING, R., PIVER, M., BAKER, T., STANTON, A., DRISCOLL, D."COMPARISON OF IFOSFAMIDE VERSUS CYCLOPHOSPHAMIDE IN COMBINATION WITH CISPLATIN AND DOXORUBICIN (ADRIAMYCIN), AS FIRST-LINE THERAPY FOR ADVANCED EPITHELIAL OVARIAN-CANCER - REPORT OF A PILOT-STUDY". Oncology Reports 1, no. 3 (1994): 631-635. https://doi.org/10.3892/or.1.3.631