SIALYL-LEWIS-X ANTIGEN IMMUNOREACTION OF COLORECTAL-CANCER AND ITS RELATIONSHIP TO HEMATOGENOUS METASTASIS

  • Authors:
    • A YAMAGUCHI
    • M SAITOH
    • T GOI
    • M DEGUCHI
    • K TAKEUCHI
    • M MAEHARA
    • K HIROSE
    • Y ISOBE
    • G NAKAGAWARA
    • S MATSUKAWA
  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/or.1.4.731
  • Pages: 731-734
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The adhesion of cancer cells to endothelial cells of the target organ is one of the most important steps of hematogenous metastasis. Especially, sialyl Le(X) plays an important role in defining the metastasis. The expression of sialyl Le(X) antigen in colorectal cancer and its usefulness not only as an indicator of metastatic potential but also as a prognostic factor was studied immunohistochemically. Fifty-five (32.4%) sialyl Le(X) antigen-positive tumors were found in 170 colorectal cancers. There was a significant correlation between the expression of sialyl Le(X) antigen and the histological tumor type, venous invasion, lymph node metastasis, as well as liver metastasis. Hematogenous metastases were significantly more frequent in patients with sialyl Le(X)-positive tumor than in those with sialyl Le(X)-negative tumor; and prognosis was significantly poorer in the former. The results suggest that sialyl Le(X) antigen plays a role in hematogenous metastasis of colorectal cancer, and that the expression of sialyl Le(X) is associated with poor prognosis.

Related Articles

Journal Cover

July 1994
Volume 1 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
YAMAGUCHI A, SAITOH M, GOI T, DEGUCHI M, TAKEUCHI K, MAEHARA M, HIROSE K, ISOBE Y, NAKAGAWARA G, MATSUKAWA S, MATSUKAWA S, et al: SIALYL-LEWIS-X ANTIGEN IMMUNOREACTION OF COLORECTAL-CANCER AND ITS RELATIONSHIP TO HEMATOGENOUS METASTASIS. Oncol Rep 1: 731-734, 1994.
APA
YAMAGUCHI, A., SAITOH, M., GOI, T., DEGUCHI, M., TAKEUCHI, K., MAEHARA, M. ... MATSUKAWA, S. (1994). SIALYL-LEWIS-X ANTIGEN IMMUNOREACTION OF COLORECTAL-CANCER AND ITS RELATIONSHIP TO HEMATOGENOUS METASTASIS. Oncology Reports, 1, 731-734. https://doi.org/10.3892/or.1.4.731
MLA
YAMAGUCHI, A., SAITOH, M., GOI, T., DEGUCHI, M., TAKEUCHI, K., MAEHARA, M., HIROSE, K., ISOBE, Y., NAKAGAWARA, G., MATSUKAWA, S."SIALYL-LEWIS-X ANTIGEN IMMUNOREACTION OF COLORECTAL-CANCER AND ITS RELATIONSHIP TO HEMATOGENOUS METASTASIS". Oncology Reports 1.4 (1994): 731-734.
Chicago
YAMAGUCHI, A., SAITOH, M., GOI, T., DEGUCHI, M., TAKEUCHI, K., MAEHARA, M., HIROSE, K., ISOBE, Y., NAKAGAWARA, G., MATSUKAWA, S."SIALYL-LEWIS-X ANTIGEN IMMUNOREACTION OF COLORECTAL-CANCER AND ITS RELATIONSHIP TO HEMATOGENOUS METASTASIS". Oncology Reports 1, no. 4 (1994): 731-734. https://doi.org/10.3892/or.1.4.731