THE ENHANCED ANTITUMOR-ACTIVITY OF DNA TOPOISOMERASE II-TRAPPING DRUGS BY NATURAL HUMAN TUMOR-NECROSIS-FACTOR AGAINST HUMAN GLIOMA CELL-LINES IN-VITRO
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- Published online on: July 1, 1994 https://doi.org/10.3892/or.1.4.735
- Pages: 735-738
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Abstract
We investigated the antitumor activity of human natural tumor necrosis factor (n-TNF) either alone or in combination with chemotherapeutic drugs on human glioma cell lines in vitro. Although the cytotoxic effect of n-TNF alone did not exceed 30%, n-TNF, in combination with topoisomerase II-trapping drugs, such as actinomycin D (ACD) and daunomycin (DAM), demonstrated a striking synergistic enhancement of the cytotoxicity, and reached a level of more than 80%, against all the tested cell lines. Thus this new combination therapy is considered to be a promising candidate in developing a new treatment approach to glioma patients.
